LAMA2
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Official Full Name
laminin, alpha 2 -
Overview
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix compo -
Synonyms
LAMA2;laminin, alpha 2;LAMM;laminin subunit alpha-2;congenital muscular dystrophy;merosin;laminin M chain;merosin heavy chain;laminin-2 subunit alpha;laminin-4 subunit alpha;laminin-12 subunit alpha
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LAMA2-27944TH | Recombinant Human LAMA2 protein, GST-tagged | Wheat Germ | Human | GST | 3013-3122 a.a. |
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| LAMA2-8310Z | Recombinant Zebrafish LAMA2 | Mammalian Cells | Zebrafish | His |
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| LAMA2-0367H | Active Recombinant Human LAMA2 protein, Fc-tagged | HEK293 | Human | Fc | 1900-2722;1573-1798;1364-1609 a.a. |
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| Lama2-210M | Recombinant Mouse Lama2 Protein, His-tagged | E.coli | Mouse | His | Ser2901~Asn3106 |
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Involved Pathway
LAMA2 involved in several pathways and played different roles in them. We selected most pathways LAMA2 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with LAMA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | ITGA9,LAMB3,COL2A1,LAMA4,FN1A,SV2A,SDC4,COL5A1,ITGB3,THBS4 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ITGB8,CACNG7,DES,ITGA3,ITGB3,ACTN1,ACTN4,ITGB6,SGCD,CACNA2D3 |
| Dilated cardiomyopathy | CACNG2,CACNB2,TGFB1,CACNG6,DES,DAG1,Itga10&Itgb1,CACNA2D1,ITGA8,PLN |
| Focal adhesion | MYL2B,VEGFAA,PIK3R1,RAC1B,MYL12B,COL6A1,PPP1R12B,RHOB,ACTG1,ITGA11A |
| Pathways in cancer | SMAD3,HHIP,PGF,RHOA,F2RL3,BRAF,CDC42,BIRC2,ITGA3,TGFA |
| Viral myocarditis | HLA-C,ACTG1,EIF4G2,HLA-DQB1,H2-AA,SGCA,HLA-F,RAC3,CD40LG,CAV1 |
| Hypertrophic cardiomyopathy (HCM) | ITGA9,PRKAG1,ITGB6,MYL2,ACE,RYR2,PRKAB1,CACNG6,ITGA1,PRKAA2 |
| Small cell lung cancer | IKBKB,ITGA2B,PIAS2,LAMA5,NFKB1,TRAF1,RXRA,LAMA3,LAMB4,ITGA6 |
| PIK-Akt signaling pathway | RELA,PDGFB,INS2,PDGFC,PPP2R2A,G6PC3,RPS6,PIK3CG,PPP2R5A,YWHAG |
Protein Function
LAMA2 has several biochemical functions, for example, receptor binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LAMA2 itself. We selected most functions LAMA2 had, and list some proteins which have the same functions with LAMA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural molecule activity | JUP,CDC42SE1,JAG1,KRT23,CLTCA,CLDN7A,KRT222,EPB41L3B,SEPT5,ANXA1 |
| receptor binding | PARK7,LIF,PPP2R4,GSDMA2,LTB,EHHADH,DHRS4,FGF8A,APOF,RAB8B |
Interacting Protein
LAMA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LAMA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of LAMA2.
DAG1;GAMMAHV.ORF33;SNAPIN;TRIM63;ENTHD2;SMC6;Naa10
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References
- Niibori-Nambu, A; Midorikawa, U; et al. Glioma Initiating Cells Form a Differentiation Niche Via the Induction of Extracellular Matrices and Integrin alpha V. PLOS ONE 8:-(2013).
- Mendell, JR; Boue, DR; et al. The congenital muscular dystrophies: Recent advances and molecular insights. PEDIATRIC AND DEVELOPMENTAL PATHOLOGY 9:427-443(2006).
