KRT6A
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Official Full Name
keratin 6A -
Overview
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. -
Synonyms
KRT6A;keratin 6A;keratin 6C , keratin 6D , KRT6C, KRT6D;keratin, type II cytoskeletal 6A;CK6C;CK6D;K6C;K6D;cytokeratin 6A;cytokeratin 6C;cytokeratin 6D;type-II keratin Kb6;keratin, epidermal type II, K6A;K6A;CK6A;KRT6C;KRT6D
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&S
- Non
- His&Fc&Avi
Involved Pathway
KRT6A involved in several pathways and played different roles in them. We selected most pathways KRT6A participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT6A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KRT6A has several biochemical functions, for example, protein binding,structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT6A itself. We selected most functions KRT6A had, and list some proteins which have the same functions with KRT6A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TRAPPC10,EHMT2,TXLNG,FGF13,FKBP3,VAMP5,GGA1,ALKBH6,MYBL2,KRT20 |
| structural molecule activity | COPG2,CRYBB2,LAMA3,KRT1-C5,JUPA,SPRR2E,CLDN11,CLDND,KRT76,INAA |
Interacting Protein
KRT6A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT6A here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT6A.
KRT15;KRT13;KRT31;HGS;SGTA
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