KPNA6
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Official Full Name
karyopherin alpha 6 (importin alpha 7) -
Overview
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. -
Synonyms
KPNA6;karyopherin alpha 6 (importin alpha 7);importin subunit alpha-7;FLJ11249;IPOA7;KPNA7;MGC17918;importin-alpha-S2;importin alpha 7 subunit;karyopherin subunit alpha-6
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
KPNA6 involved in several pathways and played different roles in them. We selected most pathways KPNA6 participated on our site, such as TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with KPNA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF-alpha/NF-kB Signaling Pathway | NKIRAS2,CAPN3,TNIP1,DDX3X,DCAF7,RNF216,PAPOLA,TXLNA,TRAIP,CSNK2A1P |
Protein Function
KPNA6 has several biochemical functions, for example, nuclear localization sequence binding,protein binding,protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KPNA6 itself. We selected most functions KPNA6 had, and list some proteins which have the same functions with KPNA6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nuclear localization sequence binding | KPNA4,TNPO1,KPNA7,BRAP,KPNA2,KPNA1,RANBP6,TNPO2,NFKBIA,IPO5 |
| protein transporter activity | AP1B1,IPO9,IPO11,CALCRL,MLC1,VPS26BL,RAMP2,CHMP7,PGAP2,AP1S3 |
| protein binding | JUP,RIMS1,DDX17,CCDC9,PRMT1,WDR61,GNB2L1,EPN2,PHB2,CD24 |
Interacting Protein
KPNA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KPNA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of KPNA6.
NOP2;NUP50;csp_playo;SPOP;CDKN1B;GABARAPL2;RELB;SKP2;Nipbl;Mki67;Nhp2l1;Ddx21;LYAR
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References
- Zaza, G; Rascio, F; et al. Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients. BMC MEDICAL GENOMICS 7:-(2014).
- Byrum, CA; Smith, J; et al. Restricted expression of karyopherin alpha mRNA in the sea urchin suggests a role in neurogenesis. GENE EXPRESSION PATTERNS 16:51-60(2014).
