KLRC2
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Official Full Name
killer cell lectin-like receptor subfamily C, member 2 -
Overview
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. -
Synonyms
KLRC2;killer cell lectin-like receptor subfamily C, member 2;NKG2-C type II integral membrane protein;CD159c;NKG2 C;NK cell receptor C;NKG2-C-activating NK receptor;CD159 antigen-like family member C;NKG2C;NKG2-C;MGC138244
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Cynomolgus
- C-hFc
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&T7
- Non
- Fc
- His&Avi
- His&Fc&Avi
- His&SUMO
Involved Pathway
KLRC2 involved in several pathways and played different roles in them. We selected most pathways KLRC2 participated on our site, such as Antigen processing and presentation,Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLRC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Antigen processing and presentation | HLA-DOB,RFXANK,KLRC3,IFNG,CTSL1,HLA-F,CD8B,HLA-DRA,TAPBP,KIR2DL3 |
| Natural killer cell mediated cytotoxicity | NFATC2,KIR2DS4,IFNA14,PPP3CB,PAK1,PIK3CG,SHC4,IFNA17,ULBP1,MAPK1 |
Protein Function
KLRC2 has several biochemical functions, for example, MHC class I protein complex binding,carbohydrate binding,protein antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLRC2 itself. We selected most functions KLRC2 had, and list some proteins which have the same functions with KLRC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | GALNTL2,KLRC1,KLRB1B,CLEC4E,Reg2,SIGLEC5,CLEC2D,LGALS9C,Il2,Chil3 |
| MHC class I protein complex binding | KLRD1,KLRC1 |
| protein binding | DDX19A,PLG,TMEM88,ACTR3,C1QBP,TEX14,KHDRBS2,LSM6,IMPDH2,TBC1D19 |
| protein antigen binding | EP300,ITGA4,H2-AB1,KLRD1 |
| transmembrane signaling receptor activity | ICAM1,CD79A,GPR113,KLRB1,HIST2H3C2,CR2,FCAMR,TLR9,FZD3A,TLR1 |
Interacting Protein
KLRC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLRC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLRC2.
TYROBP;FBP1
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