KLRB1
-
Official Full Name
killer cell lectin-like receptor subfamily B, member 1 -
Overview
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008] -
Synonyms
KLRB1;killer cell lectin-like receptor subfamily B, member 1;NKR;CD161;CLEC5B;NKR-P1;NKRP1A;NKR-P1A;hNKR-P1A;killer cell lectin-like receptor subfamily B member 1;C-type lectin domain family 5 member B;natural killer cell surface protein P1A
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Cynomolgus
- E.coli
- HEK293
- Mammalian Cells
- Insect Cells
- Wheat Germ
- His
- Non
- His&T7
- His&Avi
- His&Fc
- His&Fc&Avi
- Fc
- GST
Involved Pathway
KLRB1 involved in several pathways and played different roles in them. We selected most pathways KLRB1 participated on our site, such as Malaria, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLRB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Malaria | ICAM1,HBA2,MET,MYD88,TNF,TGFB1,IL-8,ITGB2L,HGF,ITGAL |
Protein Function
KLRB1 has several biochemical functions, for example, carbohydrate binding,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLRB1 itself. We selected most functions KLRB1 had, and list some proteins which have the same functions with KLRB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbohydrate binding | LGALS4,LGALS9C,CD207,PKD1L2,LMAN2,Clec4n,PKD1L3,SIGLEC7,HIST2H3C2,REG1B |
| transmembrane signaling receptor activity | CLEC1B,TLR1,SPN,GPR98,GIPR,Fzd4,MPL,LEPR,MARCO,ICAM1 |
Interacting Protein
KLRB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLRB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLRB1.
rpoB
Resources
Research Area
NeuroinflammationNatural Killer Cells (NK Cells) Markers
Basophils
Eosinophils
Neutrophils
gamma delta T Cells
Natural Killer T (NKT) Cells
T Follicular Helper (Tfh) Cells
Th17 Cells
Dendritic Cell Activation
Dendritic Cell Co-stimulatory Molecules
C-type Lectin Family
Related Services
Related Products
References
- Hoffmann, J; Shmeleva, EV; et al. Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients. CIRCULATION RESEARCH 116:87-U222(2015).
- Shimizu, K; Sato, Y; et al. KLRG(+) invariant natural killer T cells are long-lived effectors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:12474-12479(2014).
