KLF14
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Official Full Name
Kruppel-like factor 14 -
Overview
This gene encodes a member of the Kruppel-like family of transcription factors. The gene exhibits imprinted expression from the maternal allele in embryonic and extra-embryonic tissues. Expression of this gene is induced by TGF-beta, and the protein represses TGF-beta receptor II expression. The protein functions as part of a transcriptional co-repressor complex that also contains the transcriptional regulator SIN3A and histone deacetylase 2. -
Synonyms
KLF14;Kruppel-like factor 14;Krueppel-like factor 14;BTEB5;BTE-binding protein 5;transcription factor BTEB5;basic transcription element-binding protein 5
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- Mammalian Cell
- HEK293T
- E.coli
- Myc&DDK
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KLF14-481H |
Recombinant Human KLF14 Protein, MYC/DDK-tagged
|
HEK293 | Human | Myc&DDK |
|
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| KLF14-8678M | Recombinant Mouse KLF14 Protein | Mammalian Cell | Mouse | His |
|
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| KLF14-099H | Recombinant Human KLF14 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
|
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| Klf14-3701M | Recombinant Mouse Klf14 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
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| KLF14-4837M | Recombinant Mouse KLF14 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| KLF14-4837M-B | Recombinant Mouse KLF14 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
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| Klf14-6843R | Recombinant Rat Klf14 Protein (Full Length), N-His tagged | E.coli | Rat | His | Full L. Full Length |
|
Involved Pathway
KLF14 involved in several pathways and played different roles in them. We selected most pathways KLF14 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
KLF14 has several biochemical functions, for example, DNA binding,chromatin binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF14 itself. We selected most functions KLF14 had, and list some proteins which have the same functions with KLF14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ATP2B2,B4GALT4,RPS27A,CIZ1B,ZNF583,PAPD4,ZFP518A,ZNF324,NEURL3,ADO |
| DNA binding | ZFP668,NKX2.4B,HIST2H2AA2,ZNF593,HOXD3A,HIVEP3,EXO5,E2F1,DRL,ZNF207 |
| nucleic acid binding | EIF4A1B,CNOT4B,DPPA5A,CIZ1B,FIZ1,ZFP91,DDX4,ZNF438,ZBTB18,TOE1 |
| chromatin binding | JUB,SUPT5H,SATB1,RAN,HOXD13,CREB3L1,ATAD2,JARID2B,NEUROG1,HDAC7A |
| transcriptional activator activity, RNA polymerase II transcription factor binding | PITX1,JUN,GBX2,NOTCH1,NKX2-5,FOXH1,MED12,WWP2,LMO2,MIXL1 |
Interacting Protein
KLF14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF14 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF14.
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References
- Southwood, CM; Lipovich, L; et al. Tissue-Restricted Transcription from a Conserved Intragenic CpG Island in the Klf1 Gene in Mice. BIOLOGY OF REPRODUCTION 87:-(2012).
- Klco, JM; Kulkarni, S; et al. Immunohistochemical Analysis of Monocytic Leukemias Usefulness of CD14 and Kruppel-like Factor 4, a Novel Monocyte Marker. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 135:720-730(2011).
