KLF10

  • Official Full Name

    Kruppel-like factor 10

  • Overview

    This gene encodes a member of a family of proteins that feature C2H2-type zinc finger domains. The encoded protein is a transcriptional repressor that acts as an effector of transforming growth factor beta signaling. Activity of this protein may inhibit the growth of cancers, particularly pancreatic cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

  • Synonyms

    KLF10;Kruppel-like factor 10;EGRA;TIEG;TIEG1;EGR-alpha;Krueppel-like factor 10;early growth response-alpha;zinc finger transcription factor TIEG;TGFB-inducible early growth response protein 1;transforming growth factor-beta-inducible early growth response protein 1

Recombinant Proteins

  • Rhesus macaque
  • Rat
  • Human
  • Mouse
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&GST
  • His&T7
  • Non
  • His&Fc&Avi

    Involved Pathway

    KLF10 involved in several pathways and played different roles in them. We selected most pathways KLF10 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    KLF10 has several biochemical functions, for example, core promoter sequence-specific DNA binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF10 itself. We selected most functions KLF10 had, and list some proteins which have the same functions with KLF10. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding HOXD3,GATAD2B,RBPJ,PBX1,DMRT2A,SOX6,CEBPD,PAX7,FOXC2,CARF
    protein binding DRD1A,BLOC1S3,CLIC1,GHRHR,DOT1L,POT1,FSHB,MYO10,RARRES2,KCNH2
    core promoter sequence-specific DNA binding PPARG,SOX4,CHD2,ZFHX3,CREM,NFYA,SOX9,NRIP1,SIRT1,SOHLH1
    metal ion binding ATX1,ZFP13,SHHA,ZBTB8B,ZNF395A,NAIP1,CAHZ,STK25,PLA2G4D,ACVR1B

    Interacting Protein

    KLF10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF10 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF10.

    SP1;CDK6;TULP3;TFAP2A;RPL14;CRIP2;BOP1;SF3B3;ogl;LRRC75A-AS1;PIGC;LENG1;ZNF512B;TNS1;foxp3_human_gene;tgfb1_human_gene;MYC

    Resources

    Research Area

    Cancer Stem Cell Transcription Factors
    Epithelial Cell Markers and Intracellular Molecules

    References

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