KIR2DL1
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Official Full Name
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 -
Overview
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. -
Synonyms
KIR2DL1;killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1;killer cell immunoglobulin-like receptor 2DL1;47.11;CD158A;cl 42;nkat1;p58.1;NKAT-1;killer Ig receptor;p58 NK receptor CL-42/47.11;MHC class I NK cell receptor;killer inhibitory receptor 2-2-1;CD158 antigen-like family member A;natural killer-associated transcript 1;p58 NK cell inhibitory receptor NKR-K6;p58.1 MHC class-I-specific NK receptor;p58 killer cell inhibitory receptor KIR-K64;p58 natural killer cell receptor clones CL-42/47.11;NKAT;KIR221;KIR-K64
Recombinant Proteins
- Human
- E.coli
- HEK293
- Human Cell
- Mammalian cells
- E.coli expression system
- Non
- His
- Fc
- His&GST
- His&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KIR2DL1-145H | Recombinant Human KIR2DL1 | E.coli | Human | Non |
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| KIR2DL1-28651TH | Recombinant Human KIR2DL1 | E.coli | Human | Non | 23-223 a.a. |
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| KIR2DL1-495H | Recombinant Human KIR2DL1 Protein, His-tagged | HEK293 | Human | His | 1-245 a.a. |
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| KIR2DL1-6967H | Recombinant Human KIR2DL1 protein(Met1-His245), hFc-tagged | HEK293 | Human | Fc | 1-245 a.a. |
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| KIR2DL1-7063H | Recombinant Human KIR2DL1 protein, His & GST-tagged | E.coli | Human | His&GST | His22~Pro348 |
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| KIR2DL1-1657HCL | Recombinant Human KIR2DL1 cell lysate | Human Cell | Human | Non |
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| KIR2DL1-1701HCL | Recombinant Human KIR2DL1 cell lysate | Human Cell | Human | Non |
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| KIR2DL1-080H | Recombinant Human KIR2DL1 Protein, C-His-tagged | E.coli | Human | His |
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| KIR2DL1-1906H | Active Recombinant Human KIR2DL1 protein, Fc-tagged | HEK293 | Human | Fc | His 22 - Arg 242 |
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| KIR2DL1-3336H | Recombinant Human KIR2DL1 protein, His-tagged | E.coli | Human | His | His22~His245 |
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| KIR2DL1-4335H | Recombinant Human KIR2DL1 Protein (Met1-His245), C-His tagged | Mammalian cells | Human | His | Met1-His245 |
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| KIR2DL1-496H | Recombinant Human KIR2DL1 protein, His-Avi-tagged | HEK293 | Human | His&Avi | His22-Arg242 |
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| KIR2DL1-626HB | Recombinant Human KIR2DL1 protein, His-Avi-tagged, Biotinylated | HEK293 | Human | His&Avi | His22-Arg242 |
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| RFL27193HF | Recombinant Full Length Human Killer Cell Immunoglobulin-Like Receptor 2Dl1(Kir2Dl1) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (22-348) |
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Involved Pathway
KIR2DL1 involved in several pathways and played different roles in them. We selected most pathways KIR2DL1 participated on our site, such as Antigen processing and presentation,Natural killer cell mediated cytotoxicity,Graft-versus-host disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIR2DL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | PPP3CC,GM-CSF,RAF1,IFNA7,IFNA6,LCK,PRF1,IFNA17,IFNA1,Ifna11 |
| Graft-versus-host disease | IFNG,H2-AA,Il2,HLA-DRB1,HLA-DQA2,HLA-DRB3,KIR3DL1,PRF1,HLA-DQB1,HLA-DPA1 |
| Antigen processing and presentation | HLA-G,CTSB,HLA-DRB1,HLA-DQA1,H2-Q10,CD4,IFI30,HLA-DPA1,H2-AB1,RFXAP |
Protein Function
KIR2DL1 has several biochemical functions, for example, protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KIR2DL1 itself. We selected most functions KIR2DL1 had, and list some proteins which have the same functions with KIR2DL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | MCC,SIGLEC7,VMN1R43,NLGN4X,ITGB3A,HTR3A,NOTCH4,ITGB1B.1,PAQR5B,Pla2r1 |
| protein binding | CST1,VAV1,GABARAPL1,MYD88,RPL30,WWP1,TMED1,NCF4,NF2,MAPKAPK5 |
Interacting Protein
KIR2DL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIR2DL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIR2DL1.
PIK3R1;PTPN11;PTPN6
Resources
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References
- He, YM; Tao, SD; et al. Allelic polymorphism, mRNA and antigen expression of KIR2DL1 in the Chinese Han population. HUMAN IMMUNOLOGY 75:245-249(2014).
- Czaja, K; Borer, AS; et al. A comprehensive analysis of the binding of anti-MR antibodies to activating KIRs. GENES AND IMMUNITY 15:33-37(2014).
