KIAA0415
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Official Full Name
KIAA0415 -
Overview
This gene was identified by genome-wide screen for genes involved in homologous recombination DNA double-strand break repair (HR-DSBR). The encoded protein was found in a complex with other proteins that have a role in HR-DSBR. Knockdown of this gene reduced homologous recombination, and mutations in this gene were found in patients with spastic paraplegia. It was concluded that this gene likely encodes a helicase (PMID:20613862). -
Synonyms
KIAA0415;protein KIAA0415;SPG48;Hypothetical protein LOC9907;Uncharacterized protein KIAA0415
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Involved Pathway
KIAA0415 involved in several pathways and played different roles in them. We selected most pathways KIAA0415 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KIAA0415 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
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Protein Function
KIAA0415 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by KIAA0415 itself. We selected most functions KIAA0415 had, and list some proteins which have the same functions with KIAA0415. You can find most of the proteins on our site.
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Interacting Protein
KIAA0415 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIAA0415 here. Most of them are supplied by our site. Hope this information will be useful for your research of KIAA0415.
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References
- Fink, JK; et al. Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms. ACTA NEUROPATHOLOGICA 126:307-328(2013).
- Slabicki, M; Theis, M; et al. A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia. PLOS BIOLOGY 8:-(2010).
- Finsterer, J; Loscher, W; et al. Hereditary spastic paraplegias with autosomal dominant, recessive, X-linked, or maternal trait of inheritance. JOURNAL OF THE NEUROLOGICAL SCIENCES 318:1-18(2012).
