KDM2B
-
Official Full Name
lysine (K)-specific demethylase 2B -
Overview
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
KDM2B;lysine (K)-specific demethylase 2B;CXXC2;Fbl10;PCCX2;FBXL10;JHDM1B;lysine-specific demethylase 2B;F-box protein FBL10;F-box/LRR-repeat protein 10;CXXC-type zinc finger protein 2;protein-containing CXXC domain 2;[Histone-H3]-lysine-36 demethylase 1B;F-box and leucine-rich repeat protein 10;jumonji C domain-containing histone demethylase 1B;jmjC domain-containing histone demethylation protein 1B;JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KDM2B-40H |
Active Recombinant Human KDM2B, FLAG-tagged
|
Sf9 Cells | Human | Flag |
|
|
| KDM2B-457H | Recombinant Human KDM2B protein, FLAG-tagged | Insect Cells | Human | FLAG | 1-650 a.a. |
|
| KDM2B-8588M | Recombinant Mouse KDM2B Protein | Mammalian Cells | Mouse | His |
|
|
| KDM2B-4777M | Recombinant Mouse KDM2B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
|
| KDM2B-4777M-B | Recombinant Mouse KDM2B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
KDM2B involved in several pathways and played different roles in them. We selected most pathways KDM2B participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HDMs demethylate histones | KDM3B,KDM4D,KDM5C,ARID5B,KDM5A,KDM5BB,KDM4B,KDM6AL,KDM5D,KDM1A |
| Chromatin organization | ANO9A,SMARCB1A,KDM4B,KDM5B,ENY2,BRMS1,MSL2B,CHD4,SMARCC2,RBBP4 |
| Chromatin modifying enzymes | MBD3,SUDS3,SUZ12B,AEBP2,SUZ12A,EPC1,KANSL3,ATXN7,ING5A,ELP3 |
Protein Function
KDM2B has several biochemical functions, for example, DNA binding,histone demethylase activity,histone demethylase activity (H3-K36 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by KDM2B itself. We selected most functions KDM2B had, and list some proteins which have the same functions with KDM2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HIST1H111R,HMGB3B,ZFP451,ZNF69,HIST1H2AL,SP2,HIST1H2AA,VPS72,AHR1A,CSDE1 |
| protein binding | PRKAR2AA,ZNF488,GDI1,NMRK2,NTRK3,PIWIL1,MC3R,RAB7A,CST7,MEAF6 |
| histone demethylase activity (H3-K36 specific) | C14orf169,JHDM1D,KDM8,KDM2A,KDM4A,PHF8,JMJD5 |
| zinc ion binding | RNF114,ZDHHC15A,ATRX,SEC24A,MARCH9,BAZ2B,VDRB,MMP9,GATAD2A,ADAMTS20 |
| rRNA binding | TLR13,RPS4X,DDX21,EMG1,RPS4Y2,SBDS,RPL8,DIEXF,MRPL20,RPL23A |
| histone demethylase activity | KDM4C,PHF8,KDM1A |
Interacting Protein
KDM2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM2B here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM2B.
BCOR;SKP1;Pcgf1;PCGF1
Resources
Related Services
Related Products
References
- Gao, RT; Dong, R; et al. Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15(INK4B) and p27(Kip1). MOLECULAR AND CELLULAR BIOCHEMISTRY 379:115-122(2013).
