KDM1B
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Official Full Name
lysine (K)-specific demethylase 1B -
Overview
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009] -
Synonyms
KDM1B;lysine (K)-specific demethylase 1B;AOF1;LSD2;C6orf193;bA204B7.3;dJ298J15.2;lysine-specific histone demethylase 1B;amine oxidase, flavin containing 1;lysine-specific histone demethylase 2;amine oxidase (flavin containing) domain 1;flavin-containing amine oxidase domain-containing protein 1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AOF1-642H | Recombinant Human AOF1 protein, GST-tagged | Wheat Germ | Human | GST |
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| KDM1B-8586M | Recombinant Mouse KDM1B Protein | Mammalian Cells | Mouse | His |
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| CPBT-38112RM | Rabbit Anti-Mouse KDM1B Polyclonal Antibody | Rabbit | Mouse | Non |
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| KDM1B-1427HF | Recombinant Full Length Human KDM1B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 619 amino acids |
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| KDM1B-4776M | Recombinant Mouse KDM1B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KDM1B-4776M-B | Recombinant Mouse KDM1B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KDM1B involved in several pathways and played different roles in them. We selected most pathways KDM1B participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HDMs demethylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDM1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | TADA3,KDM4A,KDM7AB,MORF4L1,PHF15,ARID5B,C17orf81,ING5B,MCRS1,SMARCC2 |
| HDMs demethylate histones | KDM5B,KDM1A,KDM5C,KDM5A,KDM4A,KDM5D,KDM3B,KDM6AL,KDM2A,JMJD6 |
| Chromatin modifying enzymes | ELP4,PAX3A,MBIP,KDM5A,KDM4A,MEAF6,C17orf81,SMARCE1,TADA1,SUZ12 |
Protein Function
KDM1B has several biochemical functions, for example, DNA binding,N-ethylmaleimide reductase activity,NADPH:sulfur oxidoreductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KDM1B itself. We selected most functions KDM1B had, and list some proteins which have the same functions with KDM1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | ZNF2,L3MBTL1,MICAL1,SREK1IP1,TRIM65,PRKCA,ADAM19,ABLIM2,BRF1,ZCWPW2 |
| DNA binding | FBXO21,HNRPK,MEIOB,HER8.2,ANKRD1,GTF2F1,NEUROD4,TFDP1,ZNF580,NR2F6A |
| histone demethylase activity (H3-dimethyl-K4 specific) | KDM1A,KDM5BB,KDM5B |
| sulfur oxygenase reductase activity | CYBASC3,FRRS1,HEPHL1,MOSC2,CYB561A3A |
| NADPH:sulfur oxidoreductase activity | CYB561A3A,FRRS1,MOSC2,CYBASC3,MICAL2,HEPHL1,MICAL2B |
| malolactic enzyme activity | FRRS1,CYBASC3,CYB561A3A,MOSC2,HEPHL1 |
| N-ethylmaleimide reductase activity | HEPHL1,FRRS1,CYBASC3,CYB561A3A,MOSC2 |
| epoxyqueuosine reductase activity | MOSC2,HEPHL1,FRRS1,CYBASC3,CYB561A3A |
| metal ion binding | SALL3,ZNF324,ZNF256,PFKM,CYP19A1A,ADH8A,CHSY1,ZNF134,CACNA1D,ITGA6 |
Interacting Protein
KDM1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDM1B here. Most of them are supplied by our site. Hope this information will be useful for your research of KDM1B.
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References
- Gao, RT; Dong, R; et al. Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15(INK4B) and p27(Kip1). MOLECULAR AND CELLULAR BIOCHEMISTRY 379:115-122(2013).
