KDELR1
-
Official Full Name
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 -
Overview
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product. -
Synonyms
ER lumen protein retaining receptor 1;ERD2.1;ERD21_HUMAN;KDEL endoplasmic reticulum protein retention receptor 1;KDEL receptor 1;Kdelr1;Putative MAPK-activating protein PM23
Recombinant Proteins
- Rhesus macaque
- Rat
- Mouse
- Human
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Mus musculus
- Bovine
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- E.coli expression system
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
KDELR1 involved in several pathways and played different roles in them. We selected most pathways KDELR1 participated on our site, such as Vibrio cholerae infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KDELR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vibrio cholerae infection | TJP1,ACTB,ATP6V1C2,ATP6V1H,ATP6V1B1,ATP6V1F,ATP6V1C1,ATP6V1D,ACTG1,ATP6V0A4 |
Protein Function
KDELR1 has several biochemical functions, for example, KDEL sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KDELR1 itself. We selected most functions KDELR1 had, and list some proteins which have the same functions with KDELR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| KDEL sequence binding | KDELR2 |
Interacting Protein
KDELR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KDELR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KDELR1.
ctxA;Copb1;ARF1;SERINC3;SEC23A;Arfgap1;Tmed10;BZW1;BRF2;NEK6;WBP5
Resources
Related Services
Related Products
References
