KCNQ5
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Official Full Name
potassium voltage-gated channel, KQT-like subfamily, member 5 -
Overview
This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
KCNQ5;potassium voltage-gated channel, KQT-like subfamily, member 5;potassium voltage-gated channel subfamily KQT member 5;Kv7.5;KCNQ 5;KQT like 5;OTTHUMP00000064152;OTTHUMP00000064153;Potassium channel alpha subunit KvLQT5;Potassium channel protein;Potassium voltage gated channel KQT like subfamily member 5;Potassium voltage gated channel subfamily KQT member 5;Voltage gated potassium channel subunit Kv7.5;KQT-like 5;OTTHUMP00000016729;OTTHUMP00000043674;OTTHUMP00000196167;potassium channel subunit alpha KvLQT5;voltage-gated potassium channel subunit Kv7.5
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNQ5-2367R | Recombinant Rhesus monkey KCNQ5 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| KCNQ5-5016HCL | Recombinant Human KCNQ5 293 Cell Lysate | HEK293 | Human | Non |
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| KCNQ5-2188R | Recombinant Rhesus Macaque KCNQ5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| KCNQ5-2188R-B | Recombinant Rhesus Macaque KCNQ5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
KCNQ5 involved in several pathways and played different roles in them. We selected most pathways KCNQ5 participated on our site, such as Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cholinergic synapse | GNG13,PLCB2,KCNQ3,PRKACG,SLC5A7,PIK3R5,CHRNA4,CHRM4,CHRM1,KCNJ2 |
Protein Function
KCNQ5 has several biochemical functions, for example, delayed rectifier potassium channel activity,inward rectifier potassium channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ5 itself. We selected most functions KCNQ5 had, and list some proteins which have the same functions with KCNQ5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RERG,TRIM26,PSMC3,POU3F3,SYT17,TMEM27,TTR,FAM158A,HK2,BNIP3 |
| voltage-gated potassium channel activity | KCNG4A,KCND2,KCNV2B,KCNC1,KCNQ1,KCNH5A,KCNC3A,KCNS3B,KCNQ2,KCNV2 |
| inward rectifier potassium channel activity | KCNJ16,KCNJ1A.1,KCNJ1A.4,KCNJ2,KCNJ1A.2,KCNJ6,KCNH2,KCNJ1B,KCNJ14,KCNJ2A |
| delayed rectifier potassium channel activity | KCNA7,KCNS3,KCNC1,KCNC4,KCNF1,KCNA6,KCNG4A,KCNA5,KCNC1B,KCNF1A |
Interacting Protein
KCNQ5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ5.
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