KCNQ4
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Official Full Name
Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 -
Overview
The human KCNQ4 gene encodes the pore-forming subunit of Kv7.4, a voltage-gated potassium channel. KCNQ4 loss-of-function mutations cause hereditary deafness. Kv7.4 channels expressed in neurons are therapeutic targets in seizure. -
Synonyms
KCNQ4;potassium voltage-gated channel, KQT-like subfamily, member 4;DFNA2;KV7.4;DFNA2A;potassium voltage-gated channel subfamily KQT member 4;potassium channel KQT-like 4;potassium channel subunit alpha KvLQT4;voltage-gated potassium channel subunit Kv7.4;OTTHUMP00000009219;OTTHUMP00000220901;OTTHUMP00000220902;KQT-like 4;KCNQ4 Potassium Channel
Recombinant Proteins
- Mouse
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- HEK293T
- E.coli expression system
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
KCNQ4 involved in several pathways and played different roles in them. We selected most pathways KCNQ4 participated on our site, such as Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cholinergic synapse | CREB3L1,HRAS,CHRM1,PIK3CA,CREB3L3,KCNQ3,PIK3R3,PIK3R2,PIK3CD,SLC5A7 |
Protein Function
KCNQ4 has several biochemical functions, for example, delayed rectifier potassium channel activity,potassium channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ4 itself. We selected most functions KCNQ4 had, and list some proteins which have the same functions with KCNQ4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium channel activity | TRPM5,KCNS3A,KCNIP3,KCNG4A,KCNK3A,KCNC1B,KCNK4,KCNK13A,KCNH5,KCNS3B |
| protein binding | BMP4,ERLEC1,C1orf50,INS,MX1,BCDIN3D,H2-AB1,POLR2J,UBE2D1,KLRC4-KLRK1 |
| delayed rectifier potassium channel activity | KCNE1,KCNB1,KCNC1A,KCNQ5,KCNF1,KCNB2,KCNQ1,KCNS2,KCNV1,KCNV2 |
Interacting Protein
KCNQ4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ4.
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