KCNQ1
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Official Full Name
Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 1 -
Overview
The human KCNQ1 gene encodes the pore-forming subunit of Kv7.1, a voltage-gated potassium channel (also known as KvLQT1). Mutations in KCNQ1 cause an inherited form of long QT syndrome, type 1. KCNQ1 channels expressed in the heart are anti-targets in cardiac risk assessment. -
Synonyms
KCNQ1;potassium voltage-gated channel, KQT-like subfamily, member 1;LQT;RWS;WRS;LQT1;SQT2;ATFB1;ATFB3;JLNS1;KCNA8;KCNA9;Kv1.9;Kv7.1;KVLQT1;potassium voltage-gated channel subfamily KQT member 1;KQT-like 1;slow delayed rectifier channel subunit;voltage-gated potassium channel subunit Kv7.1;kidney and cardiac voltage dependend K+ channel;IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1;Jervell and Lange-Nielsen syndrome 1;FLJ26167;OTTHUMP00000011540;OTTHUMP00000011587;KCNQ1 Potassium Channel
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Human
- Guinea pig
- Xenopus laevis
- Mus musculus
- Oryctolagus cuniculus (Rabbit)
- Felis catus
- Sus scrofa (Pig)
- Squalus acanthias (Spiny dogfish)
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- His&Fc&Avi
Involved Pathway
KCNQ1 involved in several pathways and played different roles in them. We selected most pathways KCNQ1 participated on our site, such as Adrenergic signaling in cardiomyocytes,Cholinergic synapse,Gastric acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cholinergic synapse | PRKCB,CHRM3,BCL2,GNAI1,GNG7,CAMK2G,NRAS,PIK3CD,PRKACB,PIK3R3 |
| Gastric acid secretion | CCKBR,CALM3,ATP1A4,CALML3,ATP1A2,KCNJ16,ATP4A,CALM2,Adcy4,KCNJ15 |
| Potassium Channels | KCNC2,KCNN1B,KCNA2B,KCND2,KCNF1,KCNJ1A.6,KCNK3A,KCNB1,KCNJ1A.1,KCNC4 |
| Neuronal System | KCNAB2B,KCNJ1A.3,KCNH1B,ABCC9,NSFB,KCNA4,KCNG4A,CHRNA1,KCNA6A,RAB3AA |
| Protein digestion and absorption | MEP1B,COL6A6,CTRL,KCNK5,PRSS1,ATP1A3,COL6A5,MME,CELA2A,SLC7A7 |
| Adrenergic signaling in cardiomyocytes | SLC8A1,KCNE1,MYL4,MAPK14,GNAQ,CACNB3,CACNG6A,PPP1CAA,ADCY8,CALM |
| Pancreatic secretion | GNAQ,PNLIPRP1,PLA2G2D,PLCB3,CELA3A,ITPR3,PLCB2,CD38,KCNMA1,AMY2B |
| SIDS Susceptibility Pathways | MAZ,ASCL1,ECE1,CREM,PHOX2A,CTCF,SCN3B,IL1RN,EN1,PLP1 |
Protein Function
KCNQ1 has several biochemical functions, for example, calmodulin binding,delayed rectifier potassium channel activity,contributes_to delayed rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ1 itself. We selected most functions KCNQ1 had, and list some proteins which have the same functions with KCNQ1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| delayed rectifier potassium channel activity | KCNQ4,KCNQ2,KCNA5,KCNF1,KCNG2,KCNC1,KCNC1A,KCNS3,KCNV2B,KCND1 |
| protein kinase A regulatory subunit binding | AKAP7,AKAP9,RYR2,AKAP5,PJA2,ARFGEF2,ACBD3,ARFGEF1,AKAP1,C2orf88 |
| voltage-gated potassium channel activity | KCNH6A,KCNA2B,KCNH5A,KCNS3B,KCNJ11,KCNE4,KCNS3A,KCNA1,HTR3A,KCNB2 |
| scaffold protein binding | NOS3,LRP4,KRT15,KRT18,CHRNA7,PDE4D,NOS1,KCNA5,PARK7,KRT5 |
| contributes_to voltage-gated potassium channel activity | KCNE1L,KCNE1 |
| contributes_to delayed rectifier potassium channel activity | KCNE1,KCNE2 |
| protein phosphatase 1 binding | FER,PPP1R9B,PHACTR1,PPP1R15A,LILRB2,Fert2,PHACTR4,PHACTR3,SH3RF2,PHACTR3A |
| phosphatidylinositol-4,5-bisphosphate binding | PLCB1,RAG2,FAM123A,SYT1,ANXA8,TTPA,TIRAP,KLHL8,FAM21C,JPH2 |
| voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization | KCNE2,KCNH2 |
Interacting Protein
KCNQ1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ1.
KCNE1;Akap9;CALM1;GRB2;TRAF6;AKAP9
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References
- Almilaji, A; Pakladok, T; et al. Upregulation of KCNQ1/KCNE1 K+ channels by Klotho. CHANNELS 8:-(2014).
- Chadha, PS; Jepps, TA; et al. Contribution of Kv7.4/Kv7.5 Heteromers to Intrinsic and Calcitonin Gene-Related Peptide-Induced Cerebral Reactivity. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 34:887-893(2014).
