KCNMB3
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Official Full Name
potassium large conductance calcium-activated channel, subfamily M beta member 3 -
Overview
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22. -
Synonyms
KCNMB3;potassium large conductance calcium-activated channel, subfamily M beta member 3;KCNMB2, KCNMBL;calcium-activated potassium channel subunit beta-3;slo-beta-3;K(VCA)beta-3;BK channel subunit beta-3;maxi K channel subunit beta-3;charybdotoxin
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNMB3-3217R | Recombinant Rat KCNMB3 Protein | Mammalian Cell | Rat | His |
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| KCNMB3-5023HCL | Recombinant Human KCNMB3 293 Cell Lysate | HEK293 | Human | Non |
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| KCNMB3-5024HCL | Recombinant Human KCNMB3 293 Cell Lysate | HEK293 | Human | Non |
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| KCNMB3-5025HCL | Recombinant Human KCNMB3 293 Cell Lysate | HEK293 | Human | Non |
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| KCNMB3-2873R | Recombinant Rat KCNMB3 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KCNMB3-2873R-B | Recombinant Rat KCNMB3 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
KCNMB3 involved in several pathways and played different roles in them. We selected most pathways KCNMB3 participated on our site, such as cGMP-PKG signaling pathway,Vascular smooth muscle contraction,Insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNMB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin secretion | FFAR1,CAMK2G,KCNMB4,KCNN2,FXYD2,GCG,RIMS2,VAMP2,INS2,KCNJ11 |
| Vascular smooth muscle contraction | PLA2G4AA,ARHGEF11,CACNA1DA,GNA15.4,PLA2G2F,PRKCBA,MYL12.1,RHOA,MAP2K2A,PPP1R14AB |
| cGMP-PKG signaling pathway | ATF4,TRPC6,ATP1B3,ATP1A2,PPP3CC,RAF1,MYLK4,SLC25A4,NPR1,PRKG2 |
Protein Function
KCNMB3 has several biochemical functions, for example, calcium-activated potassium channel activity,potassium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNMB3 itself. We selected most functions KCNMB3 had, and list some proteins which have the same functions with KCNMB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-activated potassium channel activity | KCNMB2,MTMR6,KCNMA1,KCNN1A,KCNMB1,KCNMA1A,KCNN4,KCNN1B,CCT8L2,KCNK18 |
| potassium channel regulator activity | SGK3,PIAS3,SGK1,KCNE2,KCNV1,KCNMB2,ARPP19,KCNIP1,KCNE1,ABCC9 |
Interacting Protein
KCNMB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNMB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNMB3.
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