KCNK16
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Official Full Name
potassium channel, subfamily K, member 16 -
Overview
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. -
Synonyms
KCNK16;potassium channel, subfamily K, member 16;potassium channel subfamily K member 16;K2p16.1;TALK 1;TALK1;2P domain potassium channel Talk-1;pancreatic potassium channel Talk-1;TWIK-related alkaline pH-activated K(+) channel 1;TALK-1;MGC1331
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNK16-354HCL | Recombinant Human KCNK16 lysate | HEK293 | Human | Non |
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| RFL5253HF | Recombinant Full Length Human Potassium Channel Subfamily K Member 16(Kcnk16) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-309) |
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Involved Pathway
KCNK16 involved in several pathways and played different roles in them. We selected most pathways KCNK16 participated on our site, such as Neuronal System,Potassium Channels,TWIK-related alkaline pH activated K+ channel (TALK), which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNK16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | PANX1A,DLG3,KCNG4A,KCNN4,KCNJ1B,CHRNA4,KCNS3,KCNK3A,ARL6IP5,KCNK4 |
| Tandem pore domain potassium channels | DDX1,KCNK1B,KCNK1A,KCNK18,KCNK10B,KCNK2,KCNK13B,KCNK2B,KCNK3A,KCNK7 |
| Potassium Channels | KCNG1,KCNAB2B,KCNA1,KCNC1B,KCNH1A,KCNH6A,KCNMB2,KCNAB1A,KCNJ14,KCND3 |
Protein Function
KCNK16 has several biochemical functions, for example, potassium channel activity,potassium ion leak channel activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNK16 itself. We selected most functions KCNK16 had, and list some proteins which have the same functions with KCNK16. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GTF2F1,ADAM1B,FARSA,KITLG,RPS11,IRF9,NAA11,TSPAN2,CD151,ISOC2 |
| potassium ion leak channel activity | KCNK4,KCNK1A,KCNK10,KCNK3A,KCNK13A,KCNK15,KCNK5B,KCNK5A,KCNK13B,KCNK6 |
| voltage-gated ion channel activity | KCNS3B,SCN8AA,CLIC6,SCN8AB,ANO6,KCNC3A,KCNJ11L,SCN12AA,KCNJ1A.2,SCN1LAB |
| potassium channel activity | KCNK18,KCNIP4,KCNK5,KCNC1B,KCNA2,KCNF1A,ABCC9,KCNK13B,KCNJ11L,KCNK1A |
Interacting Protein
KCNK16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNK16 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNK16.
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References
- Lin, W; Burks, CA; et al. Taste receptor cells express pH-sensitive leak K+ channels. JOURNAL OF NEUROPHYSIOLOGY 92:2909-2919(2004).
