KCNJ2
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Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 2 -
Overview
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features. [provided by RefSeq, Jul 2008] -
Synonyms
KCNJ2;potassium inwardly-rectifying channel, subfamily J, member 2;IRK1;LQT7;SQT3;ATFB9;HHIRK1;KIR2.1;HHBIRK1;inward rectifier potassium channel 2;IRK-1;hIRK1;inward rectifier K+ channel KIR2.1;cardiac inward rectifier potassium channel
Recombinant Proteins
- Rhesus macaque
- Human
- Rat
- Chicken
- Mouse
- Bovine
- Guinea pig
- Dog
- Sus scrofa (Pig)
- Oryctolagus cuniculus (Rabbit)
- Mus musculus
- Macaca mulatta
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
KCNJ2 involved in several pathways and played different roles in them. We selected most pathways KCNJ2 participated on our site, such as Activation of G protein gated Potassium channels,Activation of GABAB receptors,Cholinergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNJ2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Classical Kir channels | KCNJ2A,KCNJ12,KCNJ4,KCNJ14 |
| Gastric acid secretion | CAMK2A,ATP4A,PLCB1,KCNE2,GNAI2,KCNJ10,CALML5,SLC9A1,KCNQ1,ATP1B3 |
| GABA B receptor activation | KCNJ6,GNGT2A,KCNJ2A,KCNJ5,GNGT2B,KCNJ12,KCNJ10,KCNJ15,KCNJ9,GNB3A |
| Activation of GABAB receptors | KCNJ6,ADCY9,ADCY6,KCNJ12,GNGT2A,KCNJ9,GNB3A,KCNJ10,KCNJ4,KCNJ3 |
| Cholinergic synapse | PRKCA,GNG10,GNAI1,GNB4,MAPK1,PLCB1,GNAI3,ACHE,GNG12,PIK3CA |
| G protein gated Potassium channels | KCNJ10,KCNJ5,KCNJ2A,KCNJ9,KCNJ15,GNGT2A,GNB3A,KCNJ6,KCNJ4,GNGT2B |
| Activation of G protein gated Potassium channels | KCNJ3,GNB3B,KCNJ12,KCNJ10,KCNJ6,KCNJ15,GNGT2B,KCNJ2A,GNGT2A,GNB3A |
| GABA receptor activation | KCNJ15,GNGT2A,KCNJ9,KCNJ12,GABRR2A,ARHGEF9,KCNJ2A,GNB3A,GNGT2B,KCNJ10 |
Protein Function
KCNJ2 has several biochemical functions, for example, identical protein binding,inward rectifier potassium channel activity,phosphatidylinositol-4,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNJ2 itself. We selected most functions KCNJ2 had, and list some proteins which have the same functions with KCNJ2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | IFIT3,TMEM115,CDC42,PTPRG,DCTPP1,CEP170L,CBS,VWF,FRS3,SNCAIP |
| inward rectifier potassium channel activity | KCNJ11L,KCNJ1A.2,KCNJ18,KCNJ1B,KCNJ14,KCNJ4,KCNJ15,KCNJ1A.5,KCNJ6,KCNK1 |
| phosphatidylinositol-4,5-bisphosphate binding | SCIN,RAB35,RAG2,PLCB1,MYO1G,PFN2,KCNJ1,SLC9A1,ASAP1,VIL1 |
| voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | KCNQ1 |
Interacting Protein
KCNJ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNJ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNJ2.
FLNA;AKAP5
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References
- Serratrice, G; Pellisser, JF; et al. Potassium channelopathies and Morvan's syndromes. BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE 194:391-406(2010).
