KCNIP2

  • Official Full Name

    Kv channel interacting protein 2

  • Overview

    This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.

  • Synonyms

    KCNIP2;Kv channel interacting protein 2;Kv channel-interacting protein 2;KCHIP2;potassium channel-interacting protein 2;A-type potassium channel modulatory protein 2;cardiac voltage-gated potassium channel modulatory subunit;MGC17241;DKFZp566L1246

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Chicken
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • HEK293T
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    KCNIP2 involved in several pathways and played different roles in them. We selected most pathways KCNIP2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNIP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Protein Function

    KCNIP2 has several biochemical functions, for example, contributes_to A-type (transient outward) potassium channel activity,A-type (transient outward) potassium channel activity,ER retention sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNIP2 itself. We selected most functions KCNIP2 had, and list some proteins which have the same functions with KCNIP2. You can find most of the proteins on our site.

    Function Related Protein
    protein N-terminus binding RPS21,CSNK2A2,EIF5A,ATM,NBN,THAP7,SMARCC1,SERPINB1A,GTF2H2,PPP1CC
    potassium channel regulator activity SUMO1,KCNMB1,NEDD4L,ARPP19,KCNAB1,ADRB2,SGK2A,SGK2,KCNV1,CHP
    identical protein binding DAAM1,WRNIP1,SMN2,TYSND1,FXR2,AMELX,PDGFB,TPD52L1,SIAH1,SDF4
    protein binding CCDC47,SVIP,JMY,TULP1,PAK1,CCDC36,DNAI2,Tnfrsf22,NCAPH,HNRNPH1
    ion channel binding YWHAE,PDE4D,GRINA,HOMER1,KCNB2,YES1,DLG1,FHL1,TRPC1,EPN1
    ER retention sequence binding KDELR3,KDELR2A,KDELR2B,KIAA1199
    calcium ion binding CDH20,EHD3,SYT5B,BMP1,NELL1,PCLO,VIL1,CDH10A,CAPN2B,VCANB
    A-type (transient outward) potassium channel activity KCND2
    contributes_to A-type (transient outward) potassium channel activity KCND3

    Interacting Protein

    KCNIP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNIP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNIP2.

    KCND2;KCNIP4

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