KCNH6
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Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 6 -
Overview
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. -
Synonyms
KCNH6;potassium voltage-gated channel, subfamily H (eag-related), member 6;potassium voltage-gated channel subfamily H member 6;erg2;HERG2;Kv11.2;eag related protein 2;ether a go go related gene potassium channel 2;potassium voltage gated channel subfamily H (eag-related), member 6;ERG-2;hERG-2;eag-related protein 2;eag-related gene member 2;ether-a-go-go-related protein 2;ether-a-go-go related gene potassium channel 2;ether-a-go-go-related gene potassium channel 2;voltage-gated potassium channel subunit Kv11.2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNH6-3369H | Recombinant Human KCNH6 protein, His-tagged | E.coli | Human | His | 1-261 aa | |
| KCNH6-3187R | Recombinant Rat KCNH6 Protein | Mammalian Cell | Rat | His |
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| KCNH6-5058HCL | Recombinant Human KCNH6 293 Cell Lysate | HEK293 | Human | Non |
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| KCNH6-2843R | Recombinant Rat KCNH6 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KCNH6-2843R-B | Recombinant Rat KCNH6 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RFL21672GF | Recombinant Full Length Chicken Potassium Voltage-Gated Channel Subfamily H Member 2(Kcnh2) Protein, His-Tagged | E.coli expression system | Chicken | His | Full L. Full Length (1-526) |
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Involved Pathway
KCNH6 involved in several pathways and played different roles in them. We selected most pathways KCNH6 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | KCNMA1,PPFIA2,PPFIA4,RAB3AB,KCNA5,KCNG4A,KCNJ14,KCNA1,SLC1A7A,KCNC2 |
| Potassium Channels | KCNK16,KCNN2,KCNN3,KCNA6A,KCNA5,KCNS3,KCNK13B,KCNH1A,KCNS3A,KCNV1 |
| Voltage gated Potassium channels | KCNC2,KCNAB1A,KCNA7,KCNC3A,KCNH2A,KCNG3,KCNA4,KCNS3,KCNH1A,KCNH5A |
Protein Function
KCNH6 has several biochemical functions, for example, voltage-gated potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH6 itself. We selected most functions KCNH6 had, and list some proteins which have the same functions with KCNH6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated potassium channel activity | KCNA2,KCNA6A,KCNQ1,KCNQ2A,KCNH2,KCNAB1,CNGA2,KCNAB1A,KCNS3B,KCND2 |
Interacting Protein
KCNH6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH6 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH6.
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References
- Huang, Q; Wu, Y; et al. Evolutionary Analysis of Voltage-Gated Potassium Channels by Bayes Method. JOURNAL OF MOLECULAR NEUROSCIENCE 53:41-49(2014).
- Proverbio, MC; Mangano, E; et al. Whole Genome SNP Genotyping and Exome Sequencing Reveal Novel Genetic Variants and Putative Causative Genes in Congenital Hyperinsulinism. PLOS ONE 8:-(2013).
