KCNH5
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Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 5 -
Overview
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. This gene is not expressed in differentiating myoblasts. Alternative splicing results in three transcript variants encoding distinct isoforms. -
Synonyms
KCNH5;potassium voltage-gated channel, subfamily H (eag-related), member 5;potassium voltage-gated channel subfamily H member 5;eag2;H EAG2;Kv10.2;hEAG2;potassium channel HEAG2;ether-a-go-go potassium channel 2;voltage-gated potassium channel EAG
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNH5-3186R | Recombinant Rat KCNH5 Protein | Mammalian Cell | Rat | His |
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| KCNH5-8502M | Recombinant Mouse KCNH5 Protein | Mammalian Cell | Mouse | His |
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| KCNH5-2842R | Recombinant Rat KCNH5 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KCNH5-2842R-B | Recombinant Rat KCNH5 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KCNH5-4732M | Recombinant Mouse KCNH5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KCNH5-4732M-B | Recombinant Mouse KCNH5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KCNH5 involved in several pathways and played different roles in them. We selected most pathways KCNH5 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | KCNH2,CHRNB2,CPLX1,KCNK1A,KCNA7,KCNK7,KCNJ1A.4,SLC6A1A,KCNV2,NSFB |
| Potassium Channels | KCNK1B,KCNH1B,KCNJ1A.1,KCNH1,KCNA6,KCNS3A,KCNK1A,KCNA1,KCNK1,KCNK13A |
| Voltage gated Potassium channels | KCNAB1,KCNH8,KCNC2,KCNH6A,KCND1,KCNH2A,KCNH5A,KCNAB3,KCNB2,KCNQ3 |
Protein Function
KCNH5 has several biochemical functions, for example, calmodulin binding,ion channel activity,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH5 itself. We selected most functions KCNH5 had, and list some proteins which have the same functions with KCNH5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| voltage-gated ion channel activity | SCN12AA,KCNIP4,CACNA2D3,CACNA1BA,CACNG1A,KCNIP1,CYBB,CATSPER2,KCNS3B,CLIC5B |
| phosphorelay sensor kinase activity | KCNH1B,KCNH1,KCNH2,CASS4,KCNH5A,KCNH8,KCNH1A |
| ion channel binding | HTT,KCNC1,ACTN1,PRNP,GRINA,CTNNB1,SRI,EPN1,HOMER1,TRPC1 |
| protein heterodimerization activity | TOP2B,VAPA,KHDRBS2,ADIPOR2,KCNK3,GCLM,UGT1A2,ZHX1,HIST1H2B5,INHA |
| ion channel activity | FXYD6,KCNC2,P2RX4B,KCNS3B,GRIN2A,TPCN1,TRPC5A,TRPC7B,SCNN1G,SCN11A |
| potassium channel activity | DDX1,KCNF1A,KCNK15,KCNA6A,KCNK16,TMEM38B,KCNJ11L,KCNK18,KCNK9,KCNF1 |
| calmodulin binding | MARCKSL1,SPA17,EPB41,MYH1,SNTB2,PCDP1,TRPC2,PHKB,ITPKB,RIT2 |
Interacting Protein
KCNH5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH5 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH5.
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References
- Schumacher-Bass, SM; Vesely, ED; et al. Role for Myosin-V Motor Proteins in the Selective Delivery of Kv Channel Isoforms to the Membrane Surface of Cardiac Myocytes. CIRCULATION RESEARCH 114:982-992(2014).
