KCNG4
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Official Full Name
potassium voltage-gated channel, subfamily G, member 4 -
Overview
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. -
Synonyms
KCNG4;potassium voltage-gated channel, subfamily G, member 4;potassium voltage-gated channel subfamily G member 4;Kv6.4;voltage-gated potassium channel Kv6.3;voltage-gated potassium channel subunit Kv6.4;KV6.3;MGC4558;MGC129609
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNG4-8497M | Recombinant Mouse KCNG4 Protein | Mammalian Cell | Mouse | His |
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| KCNG4-5061HCL | Recombinant Human KCNG4 293 Cell Lysate | HEK293 | Human | Non |
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| KCNG4-4731M | Recombinant Mouse KCNG4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KCNG4-4731M-B | Recombinant Mouse KCNG4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| RFL32178MF | Recombinant Full Length Mouse Potassium Voltage-Gated Channel Subfamily G Member 4(Kcng4) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-506) |
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| RFL723HF | Recombinant Full Length Human Potassium Voltage-Gated Channel Subfamily G Member 4(Kcng4) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-519) |
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Involved Pathway
KCNG4 involved in several pathways and played different roles in them. We selected most pathways KCNG4 participated on our site, such as Metabolic pathways,Metabolism,Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNG4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | UGT1B1,TCN1,ACOT6,ACOT2,NEU4,CYP11B1,CPNE1,CYP2D6,SLC27A2A,IDO2 |
| Metabolism of water-soluble vitamins and cofactors | SLC5A6B,SLC25A32,SLC25A32B,CYB5A,GPHNA,CTRB1,CBLC-1,SLC25A16,SLC19A2,TCN1 |
| Metabolic pathways | PGP,GM5506,UQCRC2B,NOS2A,GALNT6,P4HA2,UGP2,LTC4S,CKMT1,MGAT1A |
| Metabolism of vitamins and cofactors | GSTO2,LOC100686744,SLC52A3,SLC23A2,SLC2A3,PDZD11,MOCOS,NAMPT,SLC46A1,SLC5A6B |
| Nicotinate and nicotinamide metabolism | NT5C,NMNAT2,NT5C2B,MIBP2,MIBP,AOX2P,NT5C2,NT5C1A,NUDT12,NADKB |
Protein Function
KCNG4 has several biochemical functions, for example, ligase activity,nicotinate phosphoribosyltransferase activity,nicotinate-nucleotide diphosphorylase (carboxylating) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNG4 itself. We selected most functions KCNG4 had, and list some proteins which have the same functions with KCNG4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | TRAF6,MARCH5L,TRAIP,UBE2KB,RNF126,PELI3,TRIM41,TTLL13,UBE2CBP,TTLL11 |
| nicotinate phosphoribosyltransferase activity | NAPRT1,NAPRT |
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | NAPRT,NAMPTB,NAPRT1,NAMPT,QPRT |
| protein binding | GLTP,PTPRR,RHPN1,CROP,FGFR1OP2,HLA-DRB4,CHST13,CD8B1,MPP6,PTGES3 |
Interacting Protein
KCNG4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNG4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNG4.
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References
- Been, LF; Ralhan, S; et al. Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: A study of 3,310 subjects from India and the US. BMC MEDICAL GENETICS 12:-(2011).
- Miceli, F; Cilio, MR; et al. Gating currents from neuronal K(V)7.4 channels General features and correlation with the ionic conductance. CHANNELS 3:274-283(2009).
- Christie, MJ; et al. Molecular and functional diversity of K+ channels. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 22:944-951(1995).
