KCND3
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Official Full Name
KCND3 potassium voltage-gated channel, Shal-related subfamily, member 3 -
Overview
Potassium voltage-gated channel subfamily D member 3 also known as Kv4.3 is a protein that in humans is encoded by the KCND3 gene. It contributes to the cardiac transient outward potassium current, the main contributing current to the repolarizing phase 1 of the cardiac action potential. -
Synonyms
KCND3;potassium voltage-gated channel, Shal-related subfamily, member 3;potassium voltage-gated channel subfamily D member 3;KSHIVB;Kv4.3;voltage-gated K+ channel;potassium ionic channel Kv4.3;sha1-related potassium channel Kv4.3;voltage-gated potassium channel subunit Kv4.3;KV4.3;KCND3L;KCND3S;MGC142035;MGC142037
Recombinant Proteins
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- Human
- Oryctolagus cuniculus (Rabbit)
- Mammalian Cell
- HEK293
- E.coli
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
KCND3 involved in several pathways and played different roles in them. We selected most pathways KCND3 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCND3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuronal System | KCNK1A,PANX2,SYN2,KCNJ1A.5,KCNJ1A.2,KCNH5,CAMKK1B,KCNQ1,SLC1A2A,KCNF1 |
| Potassium Channels | KCNC3A,KCNJ14,KCNV2,ABCC9,KCNK10B,KCNK6,KCNK2B,KCNN1,KCNAB1A,KCNA6 |
| Voltage gated Potassium channels | KCNV2,KCNH6A,KCNB2,KCNQ3,KCNAB2B,KCNAB2,KCNH2,KCNA2,KCNF1A,KCNS3 |
Protein Function
KCND3 has several biochemical functions, for example, contributes_to A-type (transient outward) potassium channel activity,NOT delayed rectifier potassium channel activity,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCND3 itself. We selected most functions KCND3 had, and list some proteins which have the same functions with KCND3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT delayed rectifier potassium channel activity | KCNA4,KCND2 |
| protein binding | DEDD2,HSCB,CRBN,CDX1,HLX,TNFRSF13B,MSH6,SLX4,SNTB1,MYO15 |
| contributes_to A-type (transient outward) potassium channel activity | KCNIP2 |
| ion channel binding | HERPUD1,BAK1,PKP2,KCNQ3,FAM115C,ACTN2,DIAP1,ACTN3,TRPC1,USP10 |
| metal ion binding | ISL2A,NUBPL,GNA12,BMI1B,NUPL2,CYB5B,ZNF438,ZBED1,FXC1,FDX1B |
Interacting Protein
KCND3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCND3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCND3.
KCNIP1
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References
- Perrin, MJ; Adler, A; et al. Evaluation of Genes Encoding for the Transient Outward Current (Ito) Identifies the KCND2 Gene as a Cause of J-Wave Syndrome Associated With Sudden Cardiac Death. CIRCULATION-CARDIOVASCULAR GENETICS 7:782-U123(2014).
- Klinck, R; Fourrier, A; et al. RBFOX1 Cooperates with MBNL1 to Control Splicing in Muscle, Including Events Altered in Myotonic Dystrophy Type 1. PLOS ONE 9:-(2014).
