KCNC2
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Official Full Name
potassium voltage-gated channel, Shaw-related subfamily, member 2 -
Overview
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Three transcript variants encoding three different isoforms have been found for this gene. -
Synonyms
KCNC2;potassium voltage-gated channel, Shaw-related subfamily, member 2;potassium voltage-gated channel subfamily C member 2;Kv3.2;voltage-gated potassium channel Kv3.2;MGC138196
Recombinant Proteins
- Rat
- Zebrafish
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNC2-3174R | Recombinant Rat KCNC2 Protein | Mammalian Cell | Rat | His |
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| KCNC2-5618Z | Recombinant Zebrafish KCNC2 | Mammalian Cell | Zebrafish | His |
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| KCNC2-2830R | Recombinant Rat KCNC2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KCNC2-2830R-B | Recombinant Rat KCNC2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RFL2540RF | Recombinant Full Length Rat Potassium Voltage-Gated Channel Subfamily C Member 2(Kcnc2) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length (1-638) |
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| RFL30736HF | Recombinant Full Length Human Potassium Voltage-Gated Channel Subfamily C Member 2(Kcnc2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-638) |
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| RFL5425MF | Recombinant Full Length Mouse Potassium Voltage-Gated Channel Subfamily C Member 2(Kcnc2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-642) |
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Involved Pathway
KCNC2 involved in several pathways and played different roles in them. We selected most pathways KCNC2 participated on our site, such as Integration of energy metabolism,Metabolism,Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of insulin secretion | KCNS3,MARCKSA,KCNB1,ARL2,KCNS3A,MARCKSB,SYT5,ARL2BP |
| Integration of energy metabolism | KCNS3A,KCNB1,AKAP5,KCNJ11,RAPGEF4,RAPGEF3,ARL2,SYT5,KCNS3,GNG13A |
| Neuronal System | SLC6A12,KCNK2B,KCNA6,KCNK2,RAB3AA,SYN1,KCNG4A,KCNK3A,KCNH2A,KCNA1 |
| Metabolism | PYGMB,Agmo,ARSE,AK8,CKBA,SPTLC1,MARCKSB,CRAT,SULT1B1,STARD5 |
| Voltage gated Potassium channels | KCNA2B,KCNG4A,KCNA6A,KCNC4,KCNAB3,KCNF1A,KCNC1B,KCNA6,KCNH5A,KCNC1A |
| Potassium Channels | KCNV2,KCNA1,KCNA6,KCNQ2,KCNB1,KCNN4,KCNJ1A.3,ABCC9,KCNJ1A.5,KCNH5 |
Protein Function
KCNC2 has several biochemical functions, for example, delayed rectifier potassium channel activity,ion channel activity,potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNC2 itself. We selected most functions KCNC2 had, and list some proteins which have the same functions with KCNC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| potassium channel activity | KCNC3A,KCNK4,KCNQ2A,KCNV2,FXYD4,KCNK5A,KCNA1,KCNQ4,KCNK15,KCNK16 |
| voltage-gated ion channel activity | CACNA1SB,CX35B,CLIC4,CACNG2A,KCNC3B,SCN8AA,KCNV2,KCNJ1A.2,KCNB2,NALCN |
| voltage-gated potassium channel activity | KCNA1,CNGA5,KCNJ11,KCNK5,KCNF1A,KCNB2,KCNE3,KCNQ1,KCNQ3,CNGA1 |
| delayed rectifier potassium channel activity | KCNV1,KCNA2B,KCNF1A,KCNC1,KCNB1,KCNH1,KCNC3B,KCNS3,KCNQ5,KCNG3 |
| ion channel activity | TRPV5,CHRNB3B,CLCN6,CHRNB3A,KCNH1B,KCNC1B,GRIN2BB,TRPM5,SCN1LAB,DDX1 |
Interacting Protein
KCNC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNC2.
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References
- VEH, RW; LICHTINGHAGEN, R; et al. IMMUNOHISTOCHEMICAL LOCALIZATION OF 5 MEMBERS OF THE KV1 CHANNEL SUBUNITS - CONTRASTING SUBCELLULAR LOCATIONS AND NEURON-SPECIFIC CO-LOCALIZATIONS IN RAT-BRAIN. EUROPEAN JOURNAL OF NEUROSCIENCE 7:2189-2205(1995).
