KCNB2
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Official Full Name
potassium voltage gated channel, Shab-related subfamily, member 2 -
Overview
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both;functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart;rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell;volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in;Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel,;voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel. The gene is expressed in;gastrointestinal smooth muscle cells. -
Synonyms
KCNB2;potassium voltage gated channel, Shab-related subfamily, member 2;potassium voltage-gated channel subfamily B member 2;delayed rectifier potassium channel protein;KCNB2_HUMAN;potassium channel Kv2.2;potassium voltage gated channel subfamily B member 2;Voltage-gated potassium channel subunit Kv2.2;CDRK;Kv2.2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KCNB2-8482M | Recombinant Mouse KCNB2 Protein | Mammalian Cell | Mouse | His |
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| KCNB2-4723M | Recombinant Mouse KCNB2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| KCNB2-4723M-B | Recombinant Mouse KCNB2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KCNB2 involved in several pathways and played different roles in them. We selected most pathways KCNB2 participated on our site, such as Neuronal System,Potassium Channels,Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Potassium Channels | KCNG1,KCNQ1,KCNJ1A.4,KCNQ3,KCNS2,KCNK13B,KCND3,KCNC2,KCNAB1,KCNMB2 |
| Neuronal System | KCNH6A,KCNN1A,KCNJ1A.1,KCNK3A,SLC1A7A,KCNK13A,CACNB4B,CHRNB4,KCNH6,SLC6A12 |
| Voltage gated Potassium channels | KCNA7,KCNC4,KCNAB2B,KCND3,KCNAB2,KCNAB3,KCNA4,KCNC1,KCNV2,KCNC1A |
Protein Function
KCNB2 has several biochemical functions, for example, delayed rectifier potassium channel activity,ion channel activity,ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNB2 itself. We selected most functions KCNB2 had, and list some proteins which have the same functions with KCNB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel activity | TRPV5,GJD3,CHRNA4B,TPC3,CHRNA10A,CHRNB3A,FXYD2,SCNN1G,TRPM1B,KCNS3B |
| voltage-gated ion channel activity | CACNG7A,CLIC5,SCN1LAB,KCNH5,KCNJ1B,CACNA2D3,CATSPER2,KCNJ16,KCNIP3,KCNJ1A.3 |
| ion channel binding | SRI,GPD1L,FYN,KCNC1,CTNNB1,YWHAH,RANGRF,PRKCSH,CHERP,KCNH1 |
| potassium channel activity | KCNH5,KCNK3A,KCNK15,KCNQ2A,KCNQ4,KCNQ3,KCNK13A,KCNK5B,KCNQ2,KCNG1 |
| delayed rectifier potassium channel activity | KCNH2,KCNE1,KCNC3B,KCNV2,KCNA6,KCNV1,KCNC2,KCNQ1,KCNA6A,KCNQ2A |
| protein heterodimerization activity | HMG20A,CUL5,KCNH1,BOKB,UGT1A4,NFE2L2A,DLG4B,TAF11,ALG2,SNX6 |
| voltage-gated potassium channel activity | KCNC3A,KCNQ2,KCNK5,KCNE3,KCNH2A,CNGA3,KCNC1B,KCNE4,KCNK9,KCNC1 |
Interacting Protein
KCNB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNB2.
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References
- Cornen, S; Guille, A; et al. Candidate Luminal B Breast Cancer Genes Identified by Genome, Gene Expression and DNA Methylation Profiling. PLOS ONE 9:-(2014).
- Juang, JMJ; Lu, TP; et al. Disease-Targeted Sequencing of Ion Channel Genes identifies de novo mutations in Patients with Non-Familial Brugada Syndrome. SCIENTIFIC REPORTS 4:-(2014).
