KAZN
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Official Full Name
kazrin, periplakin interacting protein -
Overview
This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein localizes to the nucleus, desmosomes, cell membrane, and cortical actin-based structures. Some isoforms of this protein also associate with microtubules. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity has not been verified. -
Synonyms
KAZN;kazrin, periplakin interacting protein;kazrin;FLJ43806;KIAA1026;HRIHFB2003;KAZ;KAZRN_HUMAN;RP1-21O18.1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
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| KAZN-3161R | Recombinant Rat KAZN Protein | Mammalian Cells | Rat | His |
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| KAZN-912HCL | Recombinant Human KAZN cell lysate | Human | Non |
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| KAZN-147H | Recombinant Human KIAA1026 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| KAZN-2817R | Recombinant Rat KAZN Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| KAZN-2817R-B | Recombinant Rat KAZN Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Kazn-3648M | Recombinant Mouse Kazn Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
KAZN involved in several pathways and played different roles in them. We selected most pathways KAZN participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with KAZN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
KAZN has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KAZN itself. We selected most functions KAZN had, and list some proteins which have the same functions with KAZN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM104A,NPEPL1,PCK2,LRRK1,IFT88,TBC1D9B,HECTD3,NANOS3,MPDZ,EXOSC1 |
Interacting Protein
KAZN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAZN here. Most of them are supplied by our site. Hope this information will be useful for your research of KAZN.
LZTS2;COIL
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References
- Chhatriwala, MK; Cipolat, S; et al. Exons 5-15 of Kazrin Are Dispensable for Murine Epidermal Morphogenesis and Homeostasis. JOURNAL OF INVESTIGATIVE DERMATOLOGY 132:1977-1987(2012).
- Groot, KR; Sevilla, LM; et al. Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane. JOURNAL OF CELL BIOLOGY 166:653-659(2004).
