KATNA1

  • Official Full Name

    katanin p60 (ATPase containing) subunit A 1

  • Overview

    Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified.

  • Synonyms

    KATNA1;katanin p60 (ATPase containing) subunit A 1;katanin p60 ATPase-containing subunit A1;EC 3.6.4.3;Katanin p60 ATPase containing subunit A1;Katanin p60 subunit A1;KTNA1_HUMAN;OTTHUMP00000017392;OTTHUMP00000042860;p60 katanin;katanin p60 (ATPase-containing) subunit A 1

Recombinant Proteins

  • Zebrafish
  • Rat
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Mammalian Cell
  • E.coli
  • HEK293
  • His
  • His&T7
  • Non
  • His&Fc&Avi
  • N-His&C-Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
KATNA1-2784Z Recombinant Zebrafish KATNA1 Mammalian Cell Zebrafish His
KATNA1-3159R Recombinant Rat KATNA1 Protein Mammalian Cell Rat His
KATNA1-3440C Recombinant Chicken KATNA1 Mammalian Cell Chicken His
KATNA1-635C Recombinant Cynomolgus KATNA1 Protein, His-tagged Mammalian Cell Cynomolgus His
KATNA1-7877H Recombinant Human KATNA1 protein, His & T7-tagged E.coli Human His&T7 Glu8~Met229
Katna1-7878M Recombinant Mouse Katna1 protein, His & T7-tagged E.coli Mouse His&T7 Lys260~Cys491
KATNA1-888HCL Recombinant Human KATNA1 cell lysate Human Non
KATNA1-2815R Recombinant Rat KATNA1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
KATNA1-2815R-B Recombinant Rat KATNA1 Protein Pre-coupled Magnetic Beads HEK293 Rat
KATNA1-2910H Recombinant Human KATNA1 Protein (Met1-Gly168), His tagged E.coli Human His Met1-Gly168
KATNA1-2911H Recombinant Human KATNA1 Protein (Met1-Lys167), N-His tagged E.coli Human His Met1-Lys167
KATNA1-381C Recombinant Cynomolgus Monkey KATNA1 Protein, His (Fc)-Avi-tagged HEK293 Cynomolgus His&Fc&Avi
KATNA1-381C-B Recombinant Cynomolgus Monkey KATNA1 Protein Pre-coupled Magnetic Beads HEK293 Cynomolgus
KATNA1-5354H Recombinant Human KATNA1 protein, His&Myc-tagged E.coli Human N-His&C-Myc 111-491aa

    Involved Pathway

    KATNA1 involved in several pathways and played different roles in them. We selected most pathways KATNA1 participated on our site, such as Lissencephaly gene (LIS1) in neuronal migration and development, which may be useful for your reference. Also, other proteins which involved in the same pathway with KATNA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Lissencephaly gene (LIS1) in neuronal migration and development DYNLT1,VLDLR,DCX,NDEL1,LRPAP1,MAP1B,NUDC,DAB1

    Protein Function

    KATNA1 has several biochemical functions, for example, ATP binding,dynein binding,microtubule binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KATNA1 itself. We selected most functions KATNA1 had, and list some proteins which have the same functions with KATNA1. You can find most of the proteins on our site.

    Function Related Protein
    dynein binding PAFAH1B1,WDR81,DNAAF1,KATNB1,PAFAH1B1B,SERPINB1A,DCTN6,DCTN1,ATMIN,LRRC50
    ATP binding ATAD2B,PIM1,LATS1,MCCC2,MTOR,ATP6V1B1,WARS2,TOR1L3,MYO10,ATP2B2
    protein binding CDC25B,EID3,ZNF329,PSKH1,POLD2,FIBPB,MMP9,RYK,ETNK1,MAPKAPK2
    contributes_to microtubule-severing ATPase activity KATNB1
    microtubule binding CAMSAP1A,GABARAPL1,KIFC1,CAMSAP2A,KIF5B,NDEL1,NUSAP1,CEP350,CDK5RAP2,SKA1
    protein heterodimerization activity GCLC,HER11,HIST1H2AK,ZHX1,TOP2A,NFYBB,PPP1CBL,TENM3,PDSS2,SNX5

    Interacting Protein

    KATNA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KATNA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KATNA1.

    CIAO1;CD40;KATNBL1;SRSF2;AKR7A2;SORBS3;USP1;LATS1;CAPN1;SRPR;MAPT;SOAT1;SRSF3;SPTBN1;SLC30A7;KATNB1;ARHGAP39;KATNBL1;NCKAP5L

    Resources

    Research Area

    Microfilament-associated Proteins
    Microtubules

    References

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