KALRN

  • Official Full Name

    kalirin, RhoGEF kinase

  • Overview

    Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    KALRN;kalirin, RhoGEF kinase;HAPIP, huntingtin associated protein interacting protein (duo);kalirin;ARHGEF24;DUET;duo;Hs.8004;serine/threonine kinase with Dbl and pleckstrin homology domains;TRAD;huntingtin-associated protein interacti
Cat.# Product name Source (Host) Species Tag Protein Length Price
KALRN-3150R Recombinant Rat KALRN Protein Mammalian Cell Rat His
KALRN-8442M Recombinant Mouse KALRN Protein Mammalian Cell Mouse His
KALRN-2806R Recombinant Rat KALRN Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
KALRN-2806R-B Recombinant Rat KALRN Protein Pre-coupled Magnetic Beads HEK293 Rat
KALRN-4696M Recombinant Mouse KALRN Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
KALRN-4696M-B Recombinant Mouse KALRN Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KALRN involved in several pathways and played different roles in them. We selected most pathways KALRN participated on our site, such as Axon guidance,Cell death signalling via NRAGE, NRIF and NADE,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KALRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology RHOAE,BOC,MYOD1,SPNA1,PSPN,CLTA,CD24,KBTBD7,AP2B1,TRPC7
    GPCR downstream signaling DGKB,OPN4A,ABHD6B,CCK,SSTR4,PROK1,PTHLHA,ADORA3,ARHGEF1A,TIAM2
    Cell death signalling via NRAGE, NRIF and NADE ARHGAP4A,ARHGEF18,AKAP13,TRIO,OBSCN,ITGB3BP,ARHGEF1A,PLEKHG2,ARHGEF18A,BCL2L11
    Axon guidance TRPC7,RHOB,MAPK3,FGF8B,FRS2B,EPHA5,EPHA1,EFNA1A,EFNA2A,KIF4A
    G alpha (12/13) signalling events ARHGEF1B,PLEKHG2,NET1,ECT2,TIAM2,AKAP13,ARHGEF17,ARHGEF18A,GNA13B,ARHGAP4
    EPHB-mediated forward signaling EFNB3,EFNB2A,ACTR3,CFL1,KALRNB,ARPC5,ACTR2B,EPHB4B,EPHB4A,EPHB3A
    EPH-Ephrin signaling ARPC5,EFNA3B,SDCBP,MYL9,EFNB2A,ARPC1A,EFNB2,EFNB3B,CLTB,EFNB1
    G alpha (q) signalling events ANXA1C,GPR68,OPN4A,GCGA,KALRNB,ADRA1D,CHRM1,RGS21,DGKQ,PRKCHB

    Protein Function

    KALRN has several biochemical functions, for example, ATP binding,Rho guanyl-nucleotide exchange factor activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KALRN itself. We selected most functions KALRN had, and list some proteins which have the same functions with KALRN. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ERCC6L2,HSPA7,ATAD1B,P2RX3,MAPK9,DMPK,DDX58,PSMC6,SYN2B,IKBKE
    protein kinase activity EPHB2B,KITB,CLK2B,ACVR1,CAMK1GB,CASKB,MAP3K4,PTK2AA,GC2,GUCY2E
    enzyme binding TTN,JUND,FOXO4,NOXO1,LGALS9,MAPK8,DDX5,MAP2K7,RXRA,CYP2C8
    transferase activity CSNK1DA,MAPK8B,STK30,TPST1L,GAL3ST3,UGT5A1,HS3ST1L1,CKBA,STK38A,UGT5C1
    kinase activity FAM20B,FGFR1B,ERBB4A,CAMK1GB,cka1,GRK1A,GKUP,PRKCDA,CKMT2B,TLK1B
    Rho guanyl-nucleotide exchange factor activity FGD3,ARHGEF1A,FGD,PLEKHG2,PLEKHG4,TRIO,ARHGEF9,ARHGEF17,ARHGEF25,ARHGEF28
    metal ion binding PDE1C,PCK2,HDAC9,CSGALNACT1,DYTN,ADAMTS12,ZMYND15,FLYWCH1,FYNB,CNDP1
    guanyl-nucleotide exchange factor activity RIC8,ARFGEF2,FAM116B,PRSS56,TAGAP,ARHGEF7B,GAPVD1,RAPGEF4,SERGEF,RANGRF
    protein serine/threonine kinase activity HUNK,CIT,HIPK2,AKT2L,TRIOA,MAP2K5,NLK2,EIF2AK2,PIK3CG,RIPK3

    Interacting Protein

    KALRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KALRN here. Most of them are supplied by our site. Hope this information will be useful for your research of KALRN.

    HAP1;Sncaip;Grin1;Grin2b;Dlg4;Ywhab

    Resources

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All KALRN Products

    Required fields are marked with *

    My Review for All KALRN Products

    Required fields are marked with *