JMJD5
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Official Full Name
jumonji domain containing 5 -
Overview
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described. -
Synonyms
jumonji domain containing 5;lysine-specific demethylase 8;FLJ13798;EC 1.14.11.27;JmjC domain-containing protein 5;KDM8;Jumonji domain-containing protein 5;OTTHUMP00000162455
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| JMJD5-8423M | Recombinant Mouse JMJD5 Protein | Mammalian Cell | Mouse | His |
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| JMJD5-4679M | Recombinant Mouse JMJD5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| JMJD5-4679M-B | Recombinant Mouse JMJD5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
JMJD5 involved in several pathways and played different roles in them. We selected most pathways JMJD5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with JMJD5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
JMJD5 has several biochemical functions, for example, chromatin binding,dioxygenase activity,histone demethylase activity (H3-K36 specific). Some of the functions are cooperated with other proteins, some of the functions could acted by JMJD5 itself. We selected most functions JMJD5 had, and list some proteins which have the same functions with JMJD5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | TIMP1,EXT1A,NAALADL1,ZNF718,ASPA,ZBTB9,ZFP628,TRIM36,ZNF395A,HINFP |
| histone demethylase activity (H3-K36 specific) | KDM8,JHDM1D,KDM2A,KDM2B,KDM4A,C14orf169,PHF8 |
| dioxygenase activity | PHYHD1,KDM4B,OGFOD2,KDM3B,KDM5D,ALOX5A,PTGS1,KDM4D,KDM4C,KDM6A |
| oxidoreductase activity | CYP2C39,CYP3A41A,SCCPDHA,RNLS,LEPREL1,GLUD1A,CYP2K16,TYRP1B,DHRS13L1,CYP4A12A |
| chromatin binding | SSRP1A,RERE,ATRX,NKX2,DNAJC2,KAT2B,FOSL2,NR5A1A,SP110,HDAC4 |
Interacting Protein
JMJD5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JMJD5 here. Most of them are supplied by our site. Hope this information will be useful for your research of JMJD5.
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References
- Zhu, H; Hu, SJ; et al. JMJD5 Regulates Cell Cycle and Pluripotency in Human Embryonic Stem Cells. STEM CELLS 32:2098-2110(2014).
- Kawakami, E; Tokunaga, A; et al. The histone demethylase Fbxl11/Kdm2a plays an essential role in embryonic development by repressing cell-cycle regulators. MECHANISMS OF DEVELOPMENT 135:31-42(2015).
