JDP2
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Official Full Name
Jun dimerization protein 2 -
Overview
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. -
Synonyms
JDP2;Jun dimerization protein 2;JUNDM2;jun dimerization protein 2;progesterone receptor co-activator
Recombinant Proteins
- Human
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Arg
- His
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| JDP2-168H | Recombinant Human JDP2 protein, Arginine-tagged | E.coli | Human | Arg | 162 a.a. |
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| JDP2-3139R | Recombinant Rat JDP2 Protein | Mammalian Cell | Rat | His |
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| JDP2-5227C | Recombinant Chicken JDP2 | Mammalian Cell | Chicken | His |
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| JDP2-553H | Recombinant Human Jun dimerization protein 2, His-tagged | E.coli | Human | His | 1-163 a.a. |
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| JDP2-621Z | Recombinant Zebrafish JDP2 | Mammalian Cell | Zebrafish | His |
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| JDP2-8418M | Recombinant Mouse JDP2 Protein | Mammalian Cell | Mouse | His |
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| JDP2-5104HCL | Recombinant Human JDP2 293 Cell Lysate | HEK293 | Human | Non |
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| JDP2-2795R | Recombinant Rat JDP2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| JDP2-2795R-B | Recombinant Rat JDP2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| JDP2-4674M | Recombinant Mouse JDP2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| JDP2-4674M-B | Recombinant Mouse JDP2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
JDP2 involved in several pathways and played different roles in them. We selected most pathways JDP2 participated on our site, such as ATF-2 transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with JDP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ATF-2 transcription factor network | DUSP5,HRK,KCNA3,KAT5,RUVBL2,DUSP10,DDIT3,DUSP1,CDK4,MAPK14 |
Protein Function
JDP2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JDP2 itself. We selected most functions JDP2 had, and list some proteins which have the same functions with JDP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding | CLOCK,SFPI1,FOSL2,RBPJB,BATF2,RBPJL,FOSL1,MSX2,SREBF1,ARNTL2 |
| protein heterodimerization activity | POLA1,BMP2B,VOX,TBX15,HIST1H3F,JAM2A,PRMT5,ENO2,SRI,HEYL |
| chromatin binding | RAG2,NCOA3,KAT2B,TRIM24,SMAD4,PHC1,TOX2,YBX1,PYGO2,NKAP |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | BATF3,SNAI2,NFIL3,NEUROG3,PRDM5,SNAI1,PRDM1,NR2E1,ATF7,AEBP2 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | SIX4,POU1F1,DDIT3,NFYC,JUNBA,MYC,RFX1,SOX1,EBF1,ATOH1 |
| protein binding | PID1,PELO,NUDT4,TMEM120B,BABAM1,TBC1D15,USP34,CNOT8,LTBR,BEX1 |
Interacting Protein
JDP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JDP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JDP2.
Atf2;IRF2BP1;PGR;RPLP0;JUN;ATF2;JUNB;JUND;ATF7;VARS;EEF1G;EEF1D
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References
- Cibelli, G; Schoch, S; et al. Nuclear targeting of cAMP response element binding protein 2 (CREB2). EUROPEAN JOURNAL OF CELL BIOLOGY 78:642-649(1999).
- Lorenz, P; Ackermann, K; et al. Serum-stimulated cell cycle entry of fibroblasts requires undisturbed phosphorylation and non-phosphorylation interactions of the catalytic subunits of protein kinase CK2. FEBS LETTERS 448:283-288(1999).
