JARID2
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Official Full Name
jumonji, AT rich interactive domain 2 -
Overview
This gene is an ortholog of the mouse jumonji gene, which encodes a nuclear protein essential for mouse embryogenesis, including neural tube formation. Overexpression of mouse jumonji negatively regulates cell proliferation. The jumonji proteins contain a DNA-binding domain, called an AT-rich interaction domain (ARID), and share regions of similarity with human retinoblastoma-binding protein-2 and the human SMCX protein. -
Synonyms
JARID2;jumonji, AT rich interactive domain 2;JMJ, jumonji (mouse) homolog , Jumonji, AT rich interactive domain 2;protein Jumonji;JARD2;JARD2_HUMAN;JMJ;Jumonji AT rich interactive domain 2;Jumonji protein;Jumonji/ARID domain containing protein 2;Jumonji/ARID domain-containing protein 2;jumonji homolog;OTTHUMP00000016058;jumonji-like protein
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| JARID2-2976H | Recombinant Human JARID2 protein, His-tagged | E.coli | Human | His | 1130-1228 aa | |
| JARID2-2081C | Recombinant Chicken JARID2 | Mammalian Cell | Chicken | His |
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| JARID2-27632TH | Recombinant Human JARID2 | Wheat Germ | Human | Non | 100 amino acids |
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| JARID2-8416M | Recombinant Mouse JARID2 Protein | Mammalian Cell | Mouse | His |
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| JARID2-4672M | Recombinant Mouse JARID2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| JARID2-4672M-B | Recombinant Mouse JARID2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
JARID2 involved in several pathways and played different roles in them. We selected most pathways JARID2 participated on our site, such as Epigenetic regulation of gene expression,Gene Expression,PRC2 methylates histones and DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with JARID2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epigenetic regulation of gene expression | BAZ2A,RBB4L,MTF2,SUZ12B,CD3EAP,TET2,TAF1B,SMARCA5,AEBP2,EFCAB11 |
| PRC2 methylates histones and DNA | PHF19,JARID2B,PHF1,MTF2,AEBP2 |
| Signaling pathways regulating pluripotency of stem cells | AKT1,INHBE,KLF4,PIK3R2,ISL1,FGFR3,NEUROG1,FZD7,OTX1,SMAD5 |
| Gene Expression | ZNF577,NR2E3,IPO8,BRF1B,CSTF2,TNPO1,HNRNPH2,SF3B4,MBD3B,TRMT5 |
Protein Function
JARID2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,chromatin binding,NOT histone demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by JARID2 itself. We selected most functions JARID2 had, and list some proteins which have the same functions with JARID2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | TFAP2D,NHLH2,DLX2,DMRT2,ASCL3,TRP53,IRF2,SUV39H1,PHF21B,GATA3 |
| NOT histone demethylase activity | JARID2B |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | ETV6,MSX1,E4F1,AEBP1,FERD3L,BCL6AB,HES6,BCL6A,ETV3,SATB1 |
| chromatin binding | SKI,HDAC5,FABP1,ZNF143,TOX3,SNAI2,SUV39H1,CDC45,CENPA,GATA4 |
Interacting Protein
JARID2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JARID2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JARID2.
Ttll7;EED;ALB;CUL4B;EZH2;DDB1
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References
- Seok, HY; Chen, JH; et al. Loss of MicroRNA-155 Protects the Heart From Pathological Cardiac Hypertrophy. CIRCULATION RESEARCH 114:1585-1595(2014).
- Zheng, WP; Huang, YJ; et al. The chemistry and biology of the alpha-ketoglutarate-dependent histone N-epsilon-methyl-lysine demethylases. MEDCHEMCOMM 5:297-313(2014).
