ITCH
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Official Full Name
itchy E3 ubiquitin protein ligase -
Overview
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] -
Synonyms
ITCH;itchy E3 ubiquitin protein ligase;AIF4;AIP4;NAPP1;dJ468O1.1;E3 ubiquitin-protein ligase Itchy homolog;NFE2-associated polypeptide 1;atrophin-1 interacting protein 4;itchy E3 ubiquitin protein ligase homolog;dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ITCH-3094H | Recombinant Human ITCH protein | E.coli | Human | Non | Arg526-Glu903 | |
| ITCH-8480Z | Recombinant Zebrafish ITCH | Mammalian Cells | Zebrafish | His |
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| ITCH-5141HCL | Recombinant Human ITCH 293 Cell Lysate | HEK293 | Human | Non |
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| ITCH-01H | Recombinant Human ITCH protein | E.coli | Human |
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| ITCH-1255H | Recombinant Human ITCH protein | E.coli | Human | Non |
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| ITCH-5004H | Recombinant Human ITCH Protein, GST-tagged | Wheat Germ | Human | GST |
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Involved Pathway
ITCH involved in several pathways and played different roles in them. We selected most pathways ITCH participated on our site, such as Ubiquitin mediated proteolysis,Endocytosis,TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | KITB,LDLRAP1A,ARPC5L,ARPC5LB,PSD2,TSG101,GRK1B,RUFY1,IQSEC1,TSG101A |
| TNF signaling pathway | CXCL3,CREB3L1,IKBKB,TNFRSF1A,TRAF3,MAPK10,CX3CL1,TNF,RELA,FAS |
| Ubiquitin mediated proteolysis | FLJ11011L,UBE2I,FBXW7,UBE2Q1,BIRC2,SAE1,UBA6,SMURF2,CUL1A,UBE2J1 |
| Non-alcoholic fatty liver disease (NAFLD) | TRAF2,NDUFA10,PIK3CD,NDUFS5,MAPK8,COX7B,SDHA,AKT2,NDUFC1,NDUFA11 |
Protein Function
ITCH has several biochemical functions, for example, CXCR chemokine receptor binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITCH itself. We selected most functions ITCH had, and list some proteins which have the same functions with ITCH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | INTS9,SLC6A20,TLX3,NAT8,MED31,UBE2D2,ATF6,RBM12B,WDYHV1,CREB5 |
| ribonucleoprotein complex binding | YBX2,PRPF6,PES,WDR12,PRMT5,CKAP5,SECISBP2,RNASEL,BOP1,IFIH1 |
| ligase activity | RNF149,RNF144AA,TNFAIP3,RBX1,STUB1,UBR5,TRIM13,TRIM31,RNF5,CBL |
| ubiquitin protein ligase activity | TRIM32,UBE2B,CBLC,UBE2W,RNF14,UBE2C,RNF19A,SMURF1,MED7,UBE2O |
| CXCR chemokine receptor binding | CXCL12A,CXCL18B,CXCL12B,AMCF-II,PF4V1,CXCL12,IL8L2,CXCL5,CXCL1,CXCL20 |
| ubiquitin-protein transferase activity | PAX6,RNF144B,TRIM37,RNF10,UBE2T,TRIM17,UBE2G1,UBE2L3,WWP2,CMTM2A |
Interacting Protein
ITCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITCH here. Most of them are supplied by our site. Hope this information will be useful for your research of ITCH.
TP73;SGK3;SNX9;GLI1
ITCH Related Signal Pathway
Resources
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References
- Mendling, W; et al. Guideline: Vulvovaginal Candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis). MYCOSES 58:1-15(2015).
- Zandberg, DP; Rollins, S; et al. A phase I dose escalation trial of MAGE-A3-and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). CANCER IMMUNOLOGY IMMUNOTHERAPY 64:367-379(2015).
