IL11RA

  • Official Full Name

    interleukin 11 receptor, alpha

  • Overview

    Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified.

  • Synonyms

    IL11RA;interleukin 11 receptor, alpha;interleukin-11 receptor subunit alpha;hCG_2011440;I11RA_HUMAN;IL-11 receptor subunit alpha;IL-11R subunit alpha;IL-11R-alpha;IL-11RA;Interleukin 11 receptor alpha;MGC2146;OTTHUMP00000021300;OTTHUMP00000021301;OTTHUMP00000244525;OTTHUMP00000244527;OTTHUMP00000244532;interleukin-11 receptor alpha chain;CRSDA

Recombinant Proteins

  • Mouse
  • Human
  • Canine
  • Chicken
  • Zebrafish
  • HEK293
  • E.coli
  • Human Cells
  • Mammalian Cells
  • His
  • GST
  • Fc
  • Non
  • Avi&Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
Il11ra1-2294M Recombinant Mouse IL11RA protein(Met1-Gln367), His-tagged HEK293 Mouse His 1-367 a.a.
IL11RA-3155H Recombinant Human IL11RA protein, His-tagged HEK293 Human His Met1-Val363
IL11RA-561H Recombinant Human IL11RA Protein, GST-tagged E.coli Human GST 184-361 aa
IL11RA-1046C Recombinant Canine IL11RA Protein, Fc-tagged HEK293 Canine Fc 1-363 a.a.
IL11RA-1328H Recombinant Human IL11RA protein, His-tagged E.coli Human His Trp59~Pro220
IL11RA-173C Recombinant Canine IL11RA, His-tagged Human Cells Canine His Met1-Leu363
IL11RA-174C Recombinant Canine IL11RA, LEVLFQ tagged Human Cells Canine His 1-363 a.a.
IL11RA-3466C Recombinant Chicken IL11RA Mammalian Cells Chicken His
IL11RA-6298Z Recombinant Zebrafish IL11RA Mammalian Cells Zebrafish His
IL11RA-001CCL Recombinant Canine IL11RA cell lysate Human Cells Canine Non
IL11RA-2389HCL Recombinant Human IL11RA cell lysate Human Cells Human Non
IL11RA-2558MCL Recombinant Mouse IL11RA cell lysate Human Cells Mouse Non
IL11RA-0195H Active Recombinant Human IL11RA protein, His-tagged HEK293 Human His 24-370 a.a.
IL11RA-0196H Active Recombinant Human IL11RA protein, Fc-Avi-tagged, Biotinylated HEK293 Human Avi&Fc 24-370 a.a.
IL11RA-0197H Active Recombinant Human IL11RA protein, Fc-tagged HEK293 Human Fc 24-370 a.a.
IL11RA-1268C Recombinant Canine IL11RA protein(Met1-Leu363) HEK293 Canine Non Met1-Leu363

    Involved Pathway

    IL11RA involved in several pathways and played different roles in them. We selected most pathways IL11RA participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL11RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Jak-STAT signaling pathway IL6ST,CSH1,PTPN11A,AOX3L1,IFNE,MYCB,OSM,CSF3R,CRFB4,IL17D
    Hematopoietic cell lineage CD8B1,HLA-DRB5,CD1E,IL3RA,HLA-DRB1, B2M,IL5,CSF1,FLT3LG,CD8B
    Cytokine-cytokine receptor interaction IL12B,CCL4L2,PDGFAB,TNFSF11,CCL23,CCL6,CCL13,BMPR1A,IFNK,CCL27

    Protein Function

    IL11RA has several biochemical functions, for example, cytokine receptor activity,signal transducer activity,transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL11RA itself. We selected most functions IL11RA had, and list some proteins which have the same functions with IL11RA. You can find most of the proteins on our site.

    Function Related Protein
    signal transducer activity OLFR5,VALOPA,GJA1,TAAR19P,GNRHR1,DRD2B,CHRM5A,JUP,TAAR10B,TAAR14J
    transmembrane signaling receptor activity DNER,ANTXR1,CD72,CD300C,FZD7A,OR4C12,TLR7,NPC1,CD3G,EVI2A
    cytokine receptor activity IL20RB,CRFB4,IL21R.2,LIFRB,FLT3,F3B,IRX1,CRFB16,Il4ra,IL2RGA

    Interacting Protein

    IL11RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL11RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL11RA.

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family

    Research Area

    Negative Regulators of the Jak/STAT Pathway
    Receptors in the Jak/STAT Pathway
    IL-6 Family Receptors

    References

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