HYOU1

  • Official Full Name

    hypoxia up-regulated 1

  • Overview

    The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription;start sites. A cis-acting segment found in the 5 UTR is involved in stress-dependent induction, resulting in the;accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this;gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein;is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in;hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast;tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation;site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is;only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the;cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by;an amino-terminal targeting signal.

  • Synonyms

    HYOU1;hypoxia up-regulated 1;hypoxia up-regulated protein 1;glucose regulated protein 170;Grp170;HSP12A;ORP150;glucose-regulated protein 170;150 kDa oxygen-regulated protein;oxygen regulated protein (150kD);170 kDa glucose-regulated protein;GRP;GRP-170;ORP-150

Recombinant Proteins

  • Zebrafish
  • Chicken
  • Human
  • Mouse
  • Mammalian Cell
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian cells
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • Non
  • His&Fc&Avi
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
HYOU1-11978Z Recombinant Zebrafish HYOU1 Mammalian Cell Zebrafish His
HYOU1-1725C Recombinant Chicken HYOU1 Mammalian Cell Chicken His
HYOU1-30518TH Recombinant Human HYOU1, His-tagged E.coli Human His 424-999 a.a.
HYOU1-3255H Recombinant Human HYOU1 protein, His-tagged HEK293 Human His Met695-Leu994
HYOU1-7961M Recombinant Mouse HYOU1 Protein Mammalian Cell Mouse His
HYOU1-2295HCL Recombinant Human HYOU1 cell lysate Human Cell Human Non
HYOU1-2742H Recombinant Human HYOU1 Protein (Met695-Leu999), C-10×His tagged Mammalian cells Human His Met695-Leu999
HYOU1-2743H Recombinant Human HYOU1 Protein (Met695-Leu994), N-His tagged E.coli Human His Met695-Leu994
HYOU1-4395M Recombinant Mouse HYOU1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
HYOU1-4395M-B Recombinant Mouse HYOU1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
HYOU1-5215H Recombinant Human HYOU1 Protein, GST-tagged Wheat Germ Human GST
HYOU1-5744HF Recombinant Full Length Human HYOU1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 36-147 amino acids

    Involved Pathway

    HYOU1 involved in several pathways and played different roles in them. We selected most pathways HYOU1 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors,IRE1alpha activates chaperones,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with HYOU1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    XBP1(S) activates chaperone genes SEC63,WIPI1,KDELR3,DNAJB9,SERP1,C19orf10,HDGF,PDIA6,ASNA1,KLHDC3
    Scavenging by Class F Receptors HSPH1
    Binding and Uptake of Ligands by Scavenger Receptors STAB2,HP,IGKV1-5,SCGB3A2,APOBB.1,IGLC2,AMBP,IGKC,COL3A1,HSPH1
    Unfolded Protein Response (UPR) KDELR3,HDGF,YY2,PDIA6,CTDSP2,CXXC1,YIF1A,SEC63,DNAJB9,DDX11
    Vesicle-mediated transport TRAPPC10,COPZ1,GJB3,PPP6C,TFR1B,GJA8,GJA5,RAB10,MIA3,RALAA
    Protein processing in endoplasmic reticulum DNAJC5G,MOGS,HSPA4L,UBQLN1,CUL1B,RAD23A,BAG2,DNAJC5GA,PDIP5,DAD1
    Metabolism of proteins MUC1,IGFBP6B,NEU4,CTAGE5,ARSJ,GRP,PROZ,TIMM17B,MCFD2,ZDHHC2
    IRE1alpha activates chaperones KLHDC3,KDELR3,HDGF,FKBP14,SERP1,WIPI1,DDX11,CXXC1,C19orf10,PREB

    Protein Function

    HYOU1 has several biochemical functions, for example, ATP binding,chaperone binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HYOU1 itself. We selected most functions HYOU1 had, and list some proteins which have the same functions with HYOU1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NLRC3,RENBP,CNTN1B,MCM6,DDX39AA,SYN2B,MAP2K2B,ATP2B1B,TNIKA,PFKL
    chaperone binding SLC25A17,TFRC,HSPA5,DNAJB6,DLST,PRNP,CTSC,TP53,CP,DNAJB2

    Interacting Protein

    HYOU1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HYOU1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HYOU1.

    SGK1;MCC;HLA-A;HLA-A;VHL;ARF6;IKBKE;EXT2;TNFRSF10D;TRAF6;ere_dna;cona_canen;ESR1;GBA;env;Itgb1;HSPA5;H2AFX;NSS

    Resources

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