HUS1B
-
Official Full Name
HUS1 checkpoint homolog b (S. pombe) -
Overview
The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. -
Synonyms
HUS1B;HUS1 checkpoint homolog b (S. pombe);HUS1 (S. pombe) checkpoint homolog b;checkpoint protein HUS1B;hHUS1B;MGC126746;MGC126748;RP11 532F6.1;RP11-532F6.1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HUS1B-5326HCL | Recombinant Human HUS1B 293 Cell Lysate | HEK293 | Human | Non |
|
Involved Pathway
HUS1B involved in several pathways and played different roles in them. We selected most pathways HUS1B participated on our site, such as DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with HUS1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA damage response | GADD45G,DDB2,CDK5,CHEK2,TLK2,RAD9A,RAD17,RAD1,GADD45A |
Protein Function
HUS1B has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by HUS1B itself. We selected most functions HUS1B had, and list some proteins which have the same functions with HUS1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
HUS1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HUS1B here. Most of them are supplied by our site. Hope this information will be useful for your research of HUS1B.
a8k1f4_human;MLF1;HSF2;PSMD2;AARSD1;q9hav2_human;FKBPL;STUB1
Resources
Related Services
Related Products
References
- Bai, HB; Madabushi, A; et al. Interaction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1. DNA REPAIR 9:478-487(2010).
- Gembka, A; Toueille, M; et al. The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair. NUCLEIC ACIDS RESEARCH 35:2596-2608(2007).
