HTR6
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 6 -
Overview
Serotonin 5-HT6 receptors are located primarily in the striatum, olfactory tubercles, nucleus accumbens and hippocampus. Functions of 5-HT6 receptors include modulation of cholinergic and dopaminergic neurotransmission, and they have a role in spatial learning and memory. The human 5-HT6 receptor gene has been localized to chromosome 1 (1p35-36). -
Synonyms
HTR6;5-hydroxytryptamine (serotonin) receptor 6;5-hydroxytryptamine receptor 6;5 HT 6;5 HT6;5 hydroxytryptamine 6 receptor;5 hydroxytryptamine receptor 6;5-HT-6;5-HT6;5HT 6;5HT6R_HUMAN;HTR 6;Serotonin receptor 6
Recombinant Proteins
- Rat
- Chicken
- Human
- Mus musculus
- Pan troglodytes
- Mammalian Cell
- HEK293
- E.coli expression system
- His
- Non
- His&Fc&Avi
Involved Pathway
HTR6 involved in several pathways and played different roles in them. We selected most pathways HTR6 participated on our site, such as Calcium signaling pathway,cAMP signaling pathway,Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | PRKACB,ADRB2A,STIM1A,GRIN1A,ATP2A3,HTR2A,SLC25A31,CALM2B,DRD7,P2RX3 |
| cAMP signaling pathway | ORAI1,CAMK2A,HTR1F,GLI1,AKT1,GABBR2,PRKACG,MAPK9,PRKACA,CNGA2 |
| Neuroactive ligand-receptor interaction | TAAR12G,GABRD,CALCRLA,TAAR10B,GABBR2,LHB,RXFP2,CCKBR,CHRNB3B,P2RX4B |
| Serotonergic synapse | PLA2G4A,ARAF,HTR2A,HTR1E,TPH1,CYP2C38,HTR1F,HRAS,HTR7,PRKCG |
Protein Function
HTR6 has several biochemical functions, for example, histamine receptor activity,protein binding,serotonin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR6 itself. We selected most functions HTR6 had, and list some proteins which have the same functions with HTR6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| histamine receptor activity | HRH1,HRH4,HRH2,HRH3 |
| serotonin receptor activity | HTR2C,HTR4,HTR5AL,HTR3A,HTR5A,HTR1AB,HTR3C,HTR1D,HTR1B,HTR1A |
| protein binding | BNIP3L,TIMM50,LGR5,DYNC1LI1,BAIAP2L1,HIST1H2BB,SYCE2,SKIV2L2,HORMAD1,RPAP1 |
Interacting Protein
HTR6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR6 here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR6.
FYN;serotonin;lsd-lysergic acid diethylamide;fyn_crigr_protein
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References
- Ivanenkov, YA; Majouga, AG; et al. Computational approaches to the design of novel 5-HT6R ligands. REVIEWS IN THE NEUROSCIENCES 25:451-467(2014).
- Hiram, R; Rizcallah, E; et al. Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-alpha, and IL-6 in the human pulmonary artery. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 307:H1547-H1558(2014).
