HTR3C
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 3, family member C -
Overview
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit C of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. Genes encoding subunits C, D and E form a cluster on chromosome 3. -
Synonyms
HTR3C;5-hydroxytryptamine (serotonin) receptor 3, family member C;5-hydroxytryptamine receptor 3C;5 HT3 C;5 HT3C;5 hydroxytryptamine (serotonin) receptor 3, family member C;5 hydroxytryptamine receptor 3 subunit C;5 hydroxytryptamine receptor 3C;Serotonin receptor 3C;5-HT3C;5-HT3-C;5-hydroxytryptamine receptor 3 subunit C
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HTR3C-5333HCL | Recombinant Human HTR3C 293 Cell Lysate | HEK293 | Human | Non |
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| RFL36056HF | Recombinant Full Length Human 5-Hydroxytryptamine Receptor 3C(Htr3C) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (28-447) |
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Involved Pathway
HTR3C involved in several pathways and played different roles in them. We selected most pathways HTR3C participated on our site, such as Ion channel transport,Ligand-gated ion channel transport,Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR3C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | ALOX5,GNG2,GNGT1,HTR3E,GNG12,HTR3A,GNG7,MAOB,TRPC1,CYP2C70 |
| Ion channel transport | TTYH2,GABRR2A,CLCN2,ASIC1A,MCOLN2,ANO10A,TRPM1B,BEST3,ANO8,TRPC4AP |
| Ligand-gated ion channel transport | GLRBA,ARHGEF9,GABRR2A |
| Transmembrane transport of small molecules | SLC17A3,TRPM6,SLC29A3,SLC1A2A,SLC4A1B,SLC1A7B,SLC43A2,GABRR2A,SLC4A8,SLC24A6 |
Protein Function
HTR3C has several biochemical functions, for example, NOT contributes_to acetylcholine binding,NOT contributes_to acetylcholine receptor activity,NOT contributes_to acetylcholine-activated cation-selective channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR3C itself. We selected most functions HTR3C had, and list some proteins which have the same functions with HTR3C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT contributes_to acetylcholine binding | HTR3E,HTR3B,HTR3A |
| NOT contributes_to acetylcholine-activated cation-selective channel activity | HTR3B,HTR3E,HTR3A |
| protein binding | CARD10,BRCA2,AP1G2,NRG4,TADA3,Chrng,LTBR,EGLN3,BCL7B,NF2 |
| serotonin receptor activity | HTR5AL,HTR3A,HTR1B,HTR2C,HTR7,HTR4,HTR6,HTR3E,HTR2A,HTR3B |
| serotonin-activated cation-selective channel activity | HTR3A,HTR3E,HTR3B |
| NOT contributes_to acetylcholine receptor activity | HTR3E,HTR3A,HTR3B |
Interacting Protein
HTR3C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR3C here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR3C.
HTR3A
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References
- Lu, R; Alioua, A; et al. c-Src tyrosine kinase, a critical component for 5-HT(2A) receptor-mediated contraction in rat aorta. JOURNAL OF PHYSIOLOGY-LONDON 586:3855-3869(2008).
- Yoder, EJ; Tamir, H; et al. 5-Hydroxytryptamine(2A) receptors on cultured rat Schwann cells. GLIA 17:15-27(1996).
