HSPA2
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Official Full Name
heat shock 70kDa protein 2 -
Overview
Heat shock proteins (HSPs) are an important part of the cell's machinery for protein folding and help to protect cells from stress. HSPs are expressed in response to a wide variety of physiological and environmental insults including anticancer chemotherapy, thus allowing some cells to survive near lethal conditions. HSPs are expressed in tumor cell proliferation, differentiation, invasion and metastasis. In addition to improving overall protein integrity, HSP70 directly inhibits apoptosis, and has been shown to be involved in a protective role against thermal stress and cytotoxic drugs. Recently HSP70 has been reported as a prognostic marker in breast, prostate, lung and liver cancer patients -
Synonyms
HSPA2;heat shock 70kDa protein 2;heat shock 70kD protein 2;heat shock-related 70 kDa protein 2;HSP70-2;HSP70-3
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Non
- His&S
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
HSPA2 involved in several pathways and played different roles in them. We selected most pathways HSPA2 participated on our site, such as Spliceosome,MAPK signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSPA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Spliceosome | HNRPKL,RP9,SRSF5A,NCBP2,LSM7,ISY1-RAB43,SNRNP27,SNRPD3L,PRPF40A,SRSF7B |
| Toxoplasmosis | MAPK10,PIK3R1,H2-AA,NFKBIB,TYK2,CD40,PIK3CB,TNFRSF1A,MAPK3,LAMA1 |
| Legionellosis | EEF1G,VCP,HSPA1L,CASP7,SAR1B,SAR1A,PYCARD,MYD88,CXCL3,ITGAM |
| Influenza A | HLA-DRB5,IRF9,IFNB,NFKBIA,LOC100033925,EIF2AK2,Ifna15,MAPK1,IFNA4,HLA-DRB1 |
| Epstein-Barr virus infection | HLA-DRA,PIK3CA,RBPJ,HDAC4,HDAC5,SNW1,TYK2,PLCG1,SND1,YWHAZ |
| Endocytosis | SNX1,RAB11FIP4A,ARPC5LB,HSPA1A,DNAJC6,ARPC4,CHMP4A,ARR3B,CLTCB,PIP5K1AA |
| Measles | TRP53,IL12A,IFNA6,SLAMF1,IFNA8,OAS1B,TACR1,CD46,NFKB1,RAB9A |
| Antigen processing and presentation | HLA-E,CD8B,CD4,HSPA8,HSPA4,KIR3DL1,KIR2DL4,TNF,Ctsl,CANX |
| Protein processing in endoplasmic reticulum | DNAJC5G,DNAJC5B,UGGT1,CAPN1,YOD1,RPN1,UBE2G1A,FBXO6,EIF2S1B,MAPK8 |
Protein Function
HSPA2 has several biochemical functions, for example, ATP binding,enzyme binding,glycolipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSPA2 itself. We selected most functions HSPA2 had, and list some proteins which have the same functions with HSPA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | SCNM1-PS,CYP2C8,UGT1A6A,CREB1,HAND2,GOT2,Alb,EHHADH,ABCD1,CASP2 |
| protein binding | SEC23A,CYTH1,FZD8,IPO7,PXMP2,ITPR3,HBP1,FBXL5,PPP2CA,ATP5B |
| unfolded protein binding | LMAN1,DNAJB5,HSPA6,SCG5,CANX,PFDN6,HSPA1B,CALR,NPM1,GRPEL1 |
| glycolipid binding | CPTP,PLEKHA8,PRRC2B,GLTPD2,CLEC4F,GLTP,PLEKHA8P1,CD1C,GLTPD1 |
| ATP binding | PAPOLG,ABCC2,MAP3K10,P2RY1,KIF2C,MYLK4,TGFBR1B,SGK2B,VARS2,ABCG5 |
Interacting Protein
HSPA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSPA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSPA2.
HSPBP1;TRIM38;BAG4;q96be0_human;RIPK2;PPP1CC;HSF2;PSMD2;q53fc7_human;UNC45B;HSPH1
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References
- Motiei, M; Tavalaee, M; et al. Evaluation of HSPA2 in fertile and infertile individuals. ANDROLOGIA 45:66-72(2013).
- Sun, J; Wang, J; et al. Knockdown of Polycomb-Group RING Finger 6 Modulates Mouse Male Germ Cell Differentiation in Vitro. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 35:339-352(2015).
