HSH2D
-
Official Full Name
hematopoietic SH2 domain containing -
Overview
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a;costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these;signaling pathways (Greene et al., 2003 (PubMed 12960172)). -
Synonyms
HSH2D;hematopoietic SH2 domain containing;hematopoietic SH2 domain-containing protein;ALX;FLJ14886;HSH2;hematopoietic SH2 protein;adaptor in lymphocytes of unknown function X
Recombinant Proteins
- Rhesus macaque
- Zebrafish
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
HSH2D involved in several pathways and played different roles in them. We selected most pathways HSH2D participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HSH2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HSH2D has several biochemical functions, for example, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSH2D itself. We selected most functions HSH2D had, and list some proteins which have the same functions with HSH2D. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3/SH2 adaptor activity | EPS8,CNTNAP1,ITSN2,GRB14,GRB2,KHDRBS1,NCK2,ARHGAP1,ARHGAP4,SKAP2 |
Interacting Protein
HSH2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSH2D here. Most of them are supplied by our site. Hope this information will be useful for your research of HSH2D.
Resources
Related Services
Related Products
References
