HSD17B8
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Official Full Name
hydroxysteroid (17-beta) dehydrogenase 8 -
Overview
Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) as -
Synonyms
HSD17B8;hydroxysteroid (17-beta) dehydrogenase 8;FabG (beta ketoacyl [acyl carrier protein] reductase, E coli) like (E. coli) , FABGL;estradiol 17-beta-dehydrogenase 8;D6S2245E;H2 KE6;HKE6;KE6;RING2;SDR30C1;short chain dehydrogenase/reductase fa
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Cynomolgus
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
- His&Fc&Avi
Involved Pathway
HSD17B8 involved in several pathways and played different roles in them. We selected most pathways HSD17B8 participated on our site, such as Steroid hormone biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HSD17B8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ISYNA1,ATP6V0CA,NAT,GCSHB,CKB,B3GALNT1,COX5B2,MTMR1,EXT1C,HMGCL |
| Steroid hormone biosynthesis | CYP1A,UGT1A4,CYP2C55,HSD3B2,CYP2B19,CYP3A7,UGT2B7,CYP2D9,HSD17B3,CYP19A1A |
Protein Function
HSD17B8 has several biochemical functions, for example, 3-hydroxyacyl-CoA dehydrogenase activity,estradiol 17-beta-dehydrogenase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HSD17B8 itself. We selected most functions HSD17B8 had, and list some proteins which have the same functions with HSD17B8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| estradiol 17-beta-dehydrogenase activity | AKR1C6,HSD17B10,HSD17B14,HSD17B12A,RDH8,H2-KE6,HSD17B12B,HSD17B1,RDH8A,HSD17B11 |
| 3-hydroxyacyl-CoA dehydrogenase activity | HADH,HSD17B4,HADHB,HSD17B10,H2-KE6,EHHADH,HADHA,HADHAA,HADHAB |
| testosterone dehydrogenase (NAD+) activity | H2-KE6,AKR1C3,HSD17B6,HSD17B1,HSD17B2,DHRS9 |
| protein binding | TCEANC,ENTPD5,MC1R,TRAF4,EIF2S1,SID4,SVIL,DNAI2,MYBPC2,MTX2 |
Interacting Protein
HSD17B8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSD17B8 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSD17B8.
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References
- Yang, FQ; Priester, S; et al. Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 301:G981-G991(2011).
- Motohara, K; Tashiro, H; et al. Immunohistochemical analysis of 17 beta-hydroxysteroid dehydrogenase isozymes in human ovarian surface epithelium and epithelial ovarian carcinoma. MEDICAL MOLECULAR MORPHOLOGY 43:197-203(2010).
