HS3ST3A1
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Official Full Name
heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -
Overview
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. -
Synonyms
HS3ST3A1;heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1;heparan sulfate glucosamine 3-O-sulfotransferase 3A1;3OST3A1;30ST3A1;h3 OST 3A;heparan sulfate (glucosamine) 3 O sulfotransferase 3A1;Heparan sulfate 3 O sulfotransferase 3A1;Heparan sulfate D glucosaminyl 3 O sulfotransferase 3A1;3-OST-3A;h3-OST-3A;heparan sulfate 3-O-sulfotransferase 3A1;heparin-glucosamine 3-O-sulfotransferase;heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HS3ST3A1-2147R | Recombinant Rhesus monkey HS3ST3A1 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| HS3ST3A1-5052H | Recombinant Human HS3ST3A1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HS3ST3A1-817HCL | Recombinant Human HS3ST3A1 cell lysate | Human | Non |
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| HS3ST3A1-1968R | Recombinant Rhesus Macaque HS3ST3A1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| HS3ST3A1-1968R-B | Recombinant Rhesus Macaque HS3ST3A1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| HS3ST3A1-3696HF | Recombinant Full Length Human HS3ST3A1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 406 amino acids |
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Involved Pathway
HS3ST3A1 involved in several pathways and played different roles in them. We selected most pathways HS3ST3A1 participated on our site, such as Glycosaminoglycan biosynthesis - heparan sulfate / heparin, which may be useful for your reference. Also, other proteins which involved in the same pathway with HS3ST3A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | B4GALT7,HS6ST2,GLCEB,B3GALT6,EXT2,MAPK1IP1L,EXTL1,EXTL3,EXT1C,HS6ST1A |
Protein Function
HS3ST3A1 has several biochemical functions, for example, [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity,sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HS3ST3A1 itself. We selected most functions HS3ST3A1 had, and list some proteins which have the same functions with HS3ST3A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| [heparan sulfate]-glucosamine 3-sulfotransferase 3 activity | HS3ST3B1 |
| sulfotransferase activity | SULT1A2,CHST1,CHST4,HS6ST3B,SULT1C2,HS3ST2,WSCD1,HS6ST1,DSEL,SULT2ST1 |
Interacting Protein
HS3ST3A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HS3ST3A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HS3ST3A1.
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References
- Nakano, T; Shimizu, K; et al. Establishment of a human lung cancer cell line with high metastatic potential to multiple organs: Gene expression associated with metastatic potential in human lung cancer. ONCOLOGY REPORTS 28:1727-1735(2012).
- Atkinson, A; Garnier, S; et al. Genetic variations in genes involved in heparan sulphate biosynthesis are associated with Plasmodium falciparum parasitaemia: a familial study in Burkina Faso. MALARIA JOURNAL 11:-(2012).
- Joubert, BR; Franceschini, N; et al. Regulation of CCR5 Expression in Human Placenta: Insights from a Study of Mother-to-Child Transmission of HIV in Malawi. PLOS ONE 5:-(2010).
- Joubert, BR; Lange, EM; et al. A whole genome association study of mother-to-child transmission of HIV in Malawi. GENOME MEDICINE 2:-(2010).
