HRK
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Official Full Name
harakiri, BCL2 interacting protein (contains only BH3 domain) -
Overview
Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL -
Synonyms
HRK;DP5;HARAKIRI;harakiri, BCL2 interacting protein (contains only BH3 domain);activator of apoptosis hara-kiri;activator of apoptosis Hrk;Neuronal death protein DP5;BCL2-interacting protein;BH3-interacting domain-containing protein 3;death protein 5;harakiri, BCL2-interacting protein (contains only BH3 domain);BID3
Recombinant Proteins
- Rat
- Human
- Bovine
- Mus musculus
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
HRK involved in several pathways and played different roles in them. We selected most pathways HRK participated on our site, such as ATF-2 transcription factor network,Apoptosis,Apoptosis Modulation and Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Apoptosis Modulation and Signaling | PTRH2,BAG3,BLK,DIABLO,DAXX,SEPT4,BIK,PTPN13,HN1,BOK |
| Apoptosis | TNFSF10,DYNLL2,AKT3A,PIK3CA,CFLAR,PIK3R3B,CDK5RAP2,BCL2L11,IRAK1,DSG3 |
| ATF-2 transcription factor network | RUVBL2,CSRP2,DUSP1,CDK4,CBFB,DUSP10,MAPK14,GADD45A,KCNA3,JUNB |
Protein Function
HRK has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HRK itself. We selected most functions HRK had, and list some proteins which have the same functions with HRK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CBFA2T3,HPS6,C5orf30,FKBP1B,ABL2,C2orf51,MED31,MAPK11,FEM1C,CUL3 |
Interacting Protein
HRK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRK here. Most of them are supplied by our site. Hope this information will be useful for your research of HRK.
BCL2L1;C1QBP;Bcl2a1;BCL2L1;BCL2L2;Bcl2l1;C1QBP;MCL1
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References
- Sanz, C; Horita, M; et al. Fas signaling and blockade of Bcr-Abl kinase induce apoptotic Hrk protein via DREAM inhibition in human leukemia cells. HAEMATOLOGICA 87:903-907(2002).
- Jurisicova, A; Antenos, M; et al. Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation. MOLECULAR HUMAN REPRODUCTION 9:133-141(2003).
