HPS1
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Official Full Name
Hermansky-Pudlak syndrome 1 -
Overview
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is a component of three different protein complexes termed biogenesis of lysosome-related organelles complex (BLOC)-3, BLOC4, and BLOC5. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 1. Multiple transcript variants encoding distinct isoforms have been identified for this gene; the full-length sequences of some of these have not been determined yet. -
Synonyms
HPS1;Hermansky-Pudlak syndrome 1;Hermansky Pudlak syndrome , HPS;Hermansky-Pudlak syndrome 1 protein;Hermansky Pudlak syndrome 1 protein;Hermansky Pudlak syndrome gene;Hermansky Pudlak syndrome type 1;HPS;MGC5277;Hermansky-Pudlak syndrome type 1
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- His
- GST
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HPS1-13925H | Recombinant Human HPS1, His-tagged | E.coli | Human | His | 1-324a.a. | |
| HPS1-3221C | Recombinant Chicken HPS1 | Mammalian Cell | Chicken | His |
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| HPS1-3582Z | Recombinant Zebrafish HPS1 | Mammalian Cell | Zebrafish | His |
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| HPS1-5012H | Recombinant Human HPS1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HPS1-7833M | Recombinant Mouse HPS1 Protein | Mammalian Cell | Mouse | His |
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| HPS1-5397HCL | Recombinant Human HPS1 293 Cell Lysate | HEK293 | Human | Non |
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| Hps1-1857M | Recombinant Mouse Hps1 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Met1~Val275 |
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| Hps1-3435M | Recombinant Mouse Hps1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| HPS1-3629HF | Recombinant Full Length Human HPS1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 194 amino acids |
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| HPS1-4309M | Recombinant Mouse HPS1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HPS1-4309M-B | Recombinant Mouse HPS1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| HPS1-4535H | Recombinant Human HPS1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| HPS1-4739H | Recombinant Human HPS1 protein, GST-tagged | E.coli | Human | GST | 1-324aa |
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Involved Pathway
HPS1 involved in several pathways and played different roles in them. We selected most pathways HPS1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HPS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
HPS1 has several biochemical functions, for example, protein binding,protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HPS1 itself. We selected most functions HPS1 had, and list some proteins which have the same functions with HPS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CEP164,WTAP,SIRT4,NRADD,DUSP26,MAGI2,TRPM6,SLC35F6,APC,NAT8 |
| protein dimerization activity | PDCD6,PEX3,ARNTL1A,FBXW11B,GATA3,SLC4A11,HPS4,ARNTL,MEF2CA,MSGN1 |
Interacting Protein
HPS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HPS1.
HPS4;nhaA
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References
- Sarangarajan, R; Budev, A; et al. Abnormal translocation of tyrosinase and tyrosinase-related protein 1 in cutaneous melanocytes of Hermansky-Pudlak syndrome and in melanoma cells transfected with anti-sense HPS1 cDNA. JOURNAL OF INVESTIGATIVE DERMATOLOGY 117:641-646(2001).
