HPD
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Official Full Name
4-hydroxyphenylpyruvate dioxygenase -
Overview
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
HPD;4-hydroxyphenylpyruvate dioxygenase;PPD;4 HPPD;4HPPD;GLOD3;glyoxalase domain containing 3;4 hydroxyphenylpyruvate dioxygenase;4 hydroxyphenylpyruvic acid oxidase;HPPDase;OTTHUMP00000240051;OTTHUMP00000240052;4-hydroxyphenylpyruvic acid oxidase;4-HPPD
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- E.coli
- Human
- Mammalian Cell
- Wheat Germ
- HEK293
- Human Cells
- HEK293T
- In Vitro Cell Free System
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
HPD involved in several pathways and played different roles in them. We selected most pathways HPD participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis,Tyrosine metabolism,Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HPD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NME5,ACACA,PLCD4,PLA2G10,UGT1A1,NT5C3L,ADOB,AMPD3,PANK4,CYP2S1 |
| Phenylalanine metabolism | GOT1,ALDH1A3,GOT2A,MIF,IL4I1,HPDB,GOT2B,MAOB,AOC2,ALDH3B2 |
| Ubiquinone and other terpenoid-quinone biosynthesis | COQ5,COQ7,AMOTL1,HPDB,TAT,COQ2,COQ6,GGCX,HPDA,VKORC1L1 |
| Tyrosine metabolism | DBH,COMTB,TH,DCT,GOT2,MAOB,TPO,AOC3,HGD,TAT |
Protein Function
HPD has several biochemical functions, for example, 4-hydroxyphenylpyruvate dioxygenase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HPD itself. We selected most functions HPD had, and list some proteins which have the same functions with HPD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 4-hydroxyphenylpyruvate dioxygenase activity | HPDB,HPDA,HPDL |
| metal ion binding | PCGF5B,TIMM8B,HDAC5,HBB-B2,SP6,ZNF582,TRIM35-30,PCCA,MICALL2,Scd2 |
Interacting Protein
HPD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HPD here. Most of them are supplied by our site. Hope this information will be useful for your research of HPD.
HIVEP1;CDKN1A;HRSP12;IKBKG
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References
- Martinelli, M; Frati, ER; et al. Phylogeny and population dynamics of respiratory syncytial virus (Rsv) A and B. VIRUS RESEARCH 189:293-302(2014).
- da Silva, RM; et al. Anti-PD-1 monoclonal antibody Cancer immunotherapy. DRUGS OF THE FUTURE 39:15-24(2014).
