HOXD12
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Official Full Name
homeobox D12 -
Overview
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5 end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined. -
Synonyms
HOXD12;homeobox D12;homeo box D12 , HOX4H;homeobox protein Hox-D12;Homeobox protein Hox D12;Hox 4.7, mouse, homolog of;Hox 4H;HOX4H;homeo box D12;OTTHUMP00000217531;OTTHUMP00000217532;homeobox protein Hox-4H;Hox-4.7, mouse, homolog of
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXD12-6801C | Recombinant Chicken HOXD12 | Mammalian Cell | Chicken | His |
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| HOXD12-7816M | Recombinant Mouse HOXD12 Protein | Mammalian Cell | Mouse | His |
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| HOXD12-4296M | Recombinant Mouse HOXD12 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HOXD12-4296M-B | Recombinant Mouse HOXD12 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HOXD12 involved in several pathways and played different roles in them. We selected most pathways HOXD12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXD12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
HOXD12 has several biochemical functions, for example, DNA binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXD12 itself. We selected most functions HOXD12 had, and list some proteins which have the same functions with HOXD12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | TLX3B,ISX,LEF1,ZKSCAN3,SIX1A,FOXP1,SALL1A,HOXC6,IRX3B,RX3 |
| protein binding | ILF2,SLC8A1,IFIH1,ANXA7,NTHL1,METTL1,Cd24a,BTC,C1S,DNAI2 |
| DNA binding | HOXB5B,HIST1H1T,SP2,NR1D2A,ARHGEF38,SMARCC1B,TOMM20A,MSXD,ZBTB39,TFAP4 |
Interacting Protein
HOXD12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXD12 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXD12.
Meis1;Meis1
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References
- Galbo, T; Pedersen, IL; et al. Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels. EUROPEAN JOURNAL OF HISTOCHEMISTRY 54:92-98(2010).
