HOXD11
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Official Full Name
homeobox D11 -
Overview
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5 end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis. -
Synonyms
HOXD11;homeobox D11;homeo box D11 , HOX4, HOX4F;homeobox protein Hox-D11;homeo box 4F;homeo box D11;homeobox protein Hox-4F;Hox-4.6, mouse, homolog of;HOX4;HOX4F
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXD11-4992H | Recombinant Human HOXD11 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HOXD11-6188C | Recombinant Chicken HOXD11 | Mammalian Cell | Chicken | His |
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| HOXD11-3733HF | Recombinant Full Length Human HOXD11 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 338 amino acids |
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Involved Pathway
HOXD11 involved in several pathways and played different roles in them. We selected most pathways HOXD11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXD11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
HOXD11 has several biochemical functions, for example, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXD11 itself. We selected most functions HOXD11 had, and list some proteins which have the same functions with HOXD11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | SIX1A,SOX21A,NR1H5,THRA,MNX2B,E2F1,RARAB,RARGA,HLX1,NKX2.2A |
Interacting Protein
HOXD11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXD11 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXD11.
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References
- Gross, S; Krause, Y; et al. Hoxa11 and Hoxd11 Regulate Chondrocyte Differentiation Upstream of Runx2 and Shox2 in Mice. PLOS ONE 7:-(2012).
- Lee, HJ; Jang, SJ; et al. Comparison of genetic and epigenetic alterations at 11 tumor suppressor loci in pulmonary sclerosing hemangioma and adenocarcinoma. EXPERIMENTAL LUNG RESEARCH 37:344-353(2011).
