HOXD10
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Official Full Name
homeobox D10 -
Overview
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilms tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. -
Synonyms
HOXD10;homeobox D10;homeo box D10 , HOX4, HOX4D;homeobox protein Hox-D10;Hox 5.3;AI385591;AI874987;Homeo box 4D;Homeo box D10;Homeobox protein Hox-4D;Homeobox protein Hox-4E;Hox 4.4;Hox 4.5;Hox 4D;Hox 4E;HOX4D;HOX4E;HXD10;HXD10_HUMAN;OTTMUSP00000017845;RP23-313J15.9;OTTHUMP00000163335;HOX4;Hox-4.4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXD10-3653H | Recombinant Human HOXD10 protein, GST-tagged | E.coli | Human | GST | 163-247 aa | |
| HOXD10-26460TH | Recombinant Human HOXD10 | Wheat Germ | Human | Non | 100 amino acids |
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| HOXD10-4990H | Recombinant Human HOXD10 Protein, GST-tagged | Wheat Germ | Human | GST |
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| HOXD10-714H | Recombinant Human HOXD10 Protein, His-tagged | E.coli | Human | His |
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| HOXD10-5412HCL | Recombinant Human HOXD10 293 Cell Lysate | HEK293 | Human | Non |
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| HOXD10-3732HF | Recombinant Full Length Human HOXD10 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 340 amino acids |
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Involved Pathway
HOXD10 involved in several pathways and played different roles in them. We selected most pathways HOXD10 participated on our site, such as Proteoglycans in cancer,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXD10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | MAPK13,PPP1CA,MAPK1,ITGAV,ITGA5,NANOG,ARAF,DROSHA,WNT11,WNT5B |
| MicroRNAs in cancer | TNR,PDCD4,UBE2I,TRP63,ITGB3,EZH2,RHOA,MDM4,MAPK1,KIF23 |
Protein Function
HOXD10 has several biochemical functions, for example, chromatin binding,sequence-specific DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXD10 itself. We selected most functions HOXD10 had, and list some proteins which have the same functions with HOXD10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chromatin binding | ERG,NKX2-5,TADA2A,NR5A1B,SMC1A,RNF168,ZFP932,CRX,BAHCC1,RELB |
| sequence-specific DNA binding | EMX2,ZNF75D,OTPA,NR2E3,USF2,NKX2-8,VENTX,PRDM16,ZNF394,IRX5B |
| transcription factor activity, sequence-specific DNA binding | E2F3,HNF1B,ZSCAN4F,RBPJB,HDAC1,HOXB7,HOMEZB,RFX2,HOXC4A,NFE2L1A |
Interacting Protein
HOXD10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXD10 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXD10.
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References
- Xue, M; Fang, YF; et al. IGFBP3, a Transcriptional Target of Homeobox D10, Is Correlated with the Prognosis of Gastric Cancer. PLOS ONE 8:-(2013).
- Hu, X; Chen, D; et al. Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10. SCIENTIFIC REPORTS 3:-(2013).
