HOXB4
-
Official Full Name
homeobox B4 -
Overview
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. -
Synonyms
HOXB4;homeobox B4;homeo box B4 , HOX2, HOX2F;homeobox protein Hox-B4;Homeo box 2F;Homeo box B4;Homeobox 2F;Homeobox protein Hox B4;Homeobox protein HoxB4;HOX 2;Hox 2.6;Hox 2F;HOX B4;HOX2;Hox2.6;Hox2F;HOXB 4;OTTHUMP00000217026;homeobox protein Hox-2F;homeobox protein Hox-2.6;HOX-2.6
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HOXB4-13898H | Recombinant Human HOXB4, GST-tagged | E.coli | Human | GST | 22-72a.a. | |
| HOXB4-29378TH | Recombinant Human HOXB4, GST-tagged | Wheat Germ | Human | GST |
|
|
| HOXB4-6845C | Recombinant Chicken HOXB4 | Mammalian Cell | Chicken | His |
|
|
| HOXB4-5423HCL | Recombinant Human HOXB4 293 Cell Lysate | HEK293 | Human | Non |
|
|
| HOXB4-1415H | Recombinant Human HOXB4 Protein (1-251 aa), His-tagged | Yeast | Human | His | 1-251 aa |
|
| HOXB4-3622H | Recombinant Human HOXB4 Protein (Met1-Leu251), N-His tagged | E.coli | Human | His | Met1-Leu251 |
|
Involved Pathway
HOXB4 involved in several pathways and played different roles in them. We selected most pathways HOXB4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HOXB4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HOXB4 has several biochemical functions, for example, sequence-specific DNA binding,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOXB4 itself. We selected most functions HOXB4 had, and list some proteins which have the same functions with HOXB4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | HOXC6A,SCAND3,FOXG1A,FOXD2,POU3F2A,HIF1A,ZNF565,HOXC6B,KLF2,DMRT1 |
| sequence-specific DNA binding | EDF1,HNF1B,TBX3,HOXC9A,TCF7L1A,ZNF35,TRP53,RX1,PPARAB,NR1D2B |
Interacting Protein
HOXB4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOXB4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOXB4.
Resources
Related Services
Related Products
References
- Rhee, JM; Iannaccone, PM; et al. Mapping mouse hemangioblast maturation from headfold stages. DEVELOPMENTAL BIOLOGY 365:1-13(2012).
- Choi, B; Chun, E; et al. Notch-Induced hIL-6 Production Facilitates the Maintenance of Self-Renewal of hCD34(+) Cord Blood Cells Through the Activation of Jak-PI3K-STAT3 Pathway. AMERICAN JOURNAL OF PATHOLOGY 180:351-364(2012).
