HOMER2
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Official Full Name
homer homolog 2 (Drosophila) -
Overview
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. -
Synonyms
HOMER2;homer homolog 2 (Drosophila);homer protein homolog 2;CPD;Cupidin;HOMER 2;HOMER 2A;HOMER 2B;Vesl 2;ACPD;HOME2_HUMAN;Homer homolog 3;Homer neuronal immediate early gene 2;Homer-2;HOMER2A;HOMER2B;Vesl2;homer, neuronal immediate early gene, 2;VESL-2
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- E. coli
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&Myc
Involved Pathway
HOMER2 involved in several pathways and played different roles in them. We selected most pathways HOMER2 participated on our site, such as FoxO signaling pathway,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOMER2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | PIK3CA,FASLG,NLK2,CCND2A,CCNB3,NLK,FOXO1A,FOXO4,G6PCA.1,G6PC3 |
| Glutamatergic synapse | MAPK1,HOMER3,GRIN2A,PRKACA,GLS2,PLCB3,PLCB2,GLS,GLUL,GNG11 |
Protein Function
HOMER2 has several biochemical functions, for example, G-protein coupled glutamate receptor binding,GKAP/Homer scaffold activity,actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOMER2 itself. We selected most functions HOMER2 had, and list some proteins which have the same functions with HOMER2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | MITD1,CA,SKIL,GABRR3,LIN7B,TWIST2,HIST1H4D,TUBA1A,ARHGEF4,WNT1 |
| G-protein coupled glutamate receptor binding | HOMER3,HOMER1,HOMER1B |
| protein heterodimerization activity | TXLNG,HIST1H2BH,ALX1,CASP8,CXorf15,SAE1,SMC4,NEFH,DMRT3A,BIRC5 |
| protein homodimerization activity | TPD52L1,FZD9,ABCG2,GDNF,NRF1,GSTM3,DHDPSL,HSP90AA1,GDNFA,OXCT1 |
| actin binding | JMY,DMD,ALKBH4,WDR1,ADD1,HIP1RB,KLHL3,LRRC10,PHACTR3,Fert2 |
| protein binding | GIPC2,KATNA1,ILF2,HDGFRP2,TEX10,MKRN2,VRK1,OAZ1,PLA2G16,MYOT |
| GKAP/Homer scaffold activity | SHANK3,SHANK1 |
Interacting Protein
HOMER2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOMER2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOMER2.
LZTS2;RNF41;APP;KPNA2
Resources
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References
- Jing, X; Chen, SS; et al. Diagnostic Potential of Differentially Expressed Homer1, IL-1 beta, and TNF-alpha in Coronary Artery Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:535-546(2015).
- Gould, AT; Sacramento, AD; et al. Cocaine-elicited imbalances in ventromedial prefrontal cortex Homer1 versus Homer2 expression: implications for relapse. ADDICTION BIOLOGY 20:148-157(2015).
