HNRPLL
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Official Full Name
heterogeneous nuclear ribonucleoprotein L-like -
Overview
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing;of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et;al., 2008 (PubMed 18669861)). -
Synonyms
HNRPLL;heterogeneous nuclear ribonucleoprotein L-like;stromal RNA regulating factor;stromal RNA-regulating factor;SRRF;hnRNPLL
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HNRPLL-2894H | Recombinant Human HNRPLL protein, His-tagged | E.coli | Human | His | 1-70 aa | |
| HNRPLL-4919H | Recombinant Human HNRPLL Protein, GST-tagged | Wheat Germ | Human | GST |
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| HNRPLL-7773M | Recombinant Mouse HNRPLL Protein | Mammalian Cell | Mouse | His |
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| HNRPLL-5438HCL | Recombinant Human HNRPLL 293 Cell Lysate | HEK293 | Human | Non |
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| HNRPLL-3685HF | Recombinant Full Length Human HNRPLL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 542 amino acids |
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| HNRPLL-4267M | Recombinant Mouse HNRPLL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| HNRPLL-4267M-B | Recombinant Mouse HNRPLL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HNRPLL involved in several pathways and played different roles in them. We selected most pathways HNRPLL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HNRPLL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
HNRPLL has several biochemical functions, for example, mRNA binding,nucleotide binding,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HNRPLL itself. We selected most functions HNRPLL had, and list some proteins which have the same functions with HNRPLL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mRNA binding | RBM8A,PIWIL2,SOSTDC1B,PIWIL1,LUC7L2,DHFRL1,SLBP,RBMX,NUDT21,NANOS2 |
| protein binding | BAIAP2L1,NOS1AP,FAM195A,TRAPPC6B,SIGLEC5,NTHL1,NDUFAF4,CAP2,FAM86C,PRKG1 |
| nucleotide binding | CNOT4,CLK2A,RPS6KA3A,CKMT2B,PPIL4,RBM22,HNRNPC,RBM14A,ATP13A3,CPEB3 |
| poly(A) RNA binding | SEC61B,MBNL3,ROCK2,MTERF,RBM3,DDX41,PTPN1,HSP90AB1,FAM133B,CCDC124 |
Interacting Protein
HNRPLL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNRPLL here. Most of them are supplied by our site. Hope this information will be useful for your research of HNRPLL.
MDFI;DAB1;HNRNPK;HNRPK;UBE2I;BOLL
Resources
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References
- Cho, V; Mei, Y; et al. The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA. GENOME BIOLOGY 15:-(2014).
- Ergun, A; Doran, G; et al. Differential splicing across immune system lineages. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:14324-14329(2013).
